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The function of SNHG7/miR-449a/ACSL1 axis in thyroid cancer

Linchi Guo1,2, Jixuan Lu1,2, Jie Gao1,2

  • 1Department of Endocrinology, The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, China.

Journal of Cellular Biochemistry
|January 22, 2020
PubMed

Insights

Small nucleolar RNA host gene 7 (SNHG7) promotes thyroid cancer (TC) progression by sponging microRNA-449a (miR-449a) and upregulating Acyl-CoA synthetase long-chain family member 1 (ACSL1). This study elucidates a novel regulatory mechanism in TC development.

Area of Science:

  • Endocrinology
  • Molecular Biology
  • Oncology

Background:

  • Thyroid cancer (TC) is the most prevalent endocrine malignancy.
  • The role and mechanism of Small nucleolar RNA host gene 7 (SNHG7) in TC remain unclear.
  • Acyl-CoA synthetase long-chain family member 1 (ACSL1) is implicated as an oncogene in various cancers.

Purpose of the Study:

  • To investigate the role of SNHG7 in thyroid cancer progression.
  • To elucidate the underlying molecular mechanism involving microRNA-449a (miR-449a) and ACSL1.
  • To explore SNHG7 as a potential therapeutic target in TC.

Main Methods:

  • Quantitative real-time PCR to assess SNHG7 expression.
  • SNHG7 knockdown and ACSL1 overexpression in TC cell lines.
  • Bioinformatics analysis, RNA immunoprecipitation, and luciferase reporter assays to validate molecular interactions.

Main Results:

  • SNHG7 expression is significantly upregulated in TC cell lines.
  • SNHG7 knockdown suppresses TC cell proliferation and migration.
  • SNHG7 acts as a molecular sponge for miR-449a, leading to increased ACSL1 expression, which promotes TC progression.

Conclusions:

  • SNHG7 promotes thyroid cancer cell proliferation and migration via the SNHG7/miR-449a/ACSL1 axis.
  • This finding reveals a novel regulatory pathway for long noncoding RNAs in TC.
  • Targeting the SNHG7/miR-449a/ACSL1 pathway may offer a new therapeutic strategy for TC.
Keywords:
ACSL1SNHG7miR-449athyroid cancer

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