[Sensitivity to cephalosporin antibiotics of infectious causative agents in surgery]

Comparison of antimicrobial effects of cephalosporins of the 1st and 2nd generations showed that the latter were advantageous with respect to gram-negative bacteria causing surgical infections. Three cephalosporins of the 3rd generation were characterized by the highest activity against such bacteria, including Enterobacter spp. and indole positive strains of Proteus spp., as well as non-enzymatic bacteria. The antimicrobial spectra and MICs of the new cephalosporins with respect to the cultures isolated from surgical patients were different which requires in vitro sensitivity assay of each antibiotic.