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Updated: Dec 30, 2025

Aptamer-Based Target Detection Facilitated by a 3-Stage G-Quadruplex Isothermal Exponential Amplification Reaction
Published on: October 6, 2022
Utilization of G-Quadruplex-Forming Aptamers for the Construction of Luminescence Sensing Platforms
Dik-Lung Ma1, Wanhe Wang1, Zhifeng Mao1
1Department of Chemistry, Hong Kong Baptist University, 224 Waterloo Road, Kowloon Tong, Hong Kong, 852, P. R. China.
Abstract:
Aptamers are nucleic acid sequences that can recognize and bind to analytes with high affinity and selectivity. Intriguingly, a number of aptamers undergo a conformational change within the G-quadruplex motif upon ligand binding. This Minireview aims to highlight interesting examples of luminescent G-quadruplex aptamer-based probes that have been developed in recent years. Various mechanisms and sensing modes are described, and the outlook and future directions of this field are also discussed.
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