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Effect of strontium chloride on bone resorption induced by prostaglandin E2 in cultured bone
1Department of Dental Pharmacology, School of Dentistry, Hokkaido University, Sapporo, Japan.
Archives of Toxicology
|January 1, 1988
Abstract:
We examined whether the bone resorption induced by PGE2 was inhibited by SrCl2 using 45Ca-labelled calvaria of CD-strain mice in tissue culture. It was found that Sr salts inhibited physiological bone resorption in a dose-dependent manner (0.1-5.0 mM) and did not act via PGE2. Accordingly, it was suggested that Sr salts did not inhibit bone resorption induced by exogenous PGE2.