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Related Experiment Video

Updated: Dec 30, 2025

Self-assembly of Complex Two-dimensional Shapes from Single-stranded DNA Tiles

Self-assembly of Complex Two-dimensional Shapes from Single-stranded DNA Tiles

Published on: May 8, 2015

Peptide-Driven Shape Control of Low-Dimensional DNA Nanostructures.

Chan-Jin Kim¹, Ji-Eun Park¹, Xiaole Hu¹

¹Department of Chemistry and Nanoscience , Ewha Womans University , 52 Ewhayeodae-gil, Seodaemun-gu , Seoul 03760 , Korea.

|January 22, 2020

Summary

Researchers created novel DNA nanostructures using peptide interactions. These DNA-peptide copolymers self-assemble into diverse low-dimensional forms like fibers and ribbons, offering a new method for dynamic nanomaterial fabrication.

Keywords:

DNA block copolymer nanofiber nanosheet peptide self-assembly

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Last Updated: Dec 30, 2025

Self-assembly of Complex Two-dimensional Shapes from Single-stranded DNA Tiles

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Published on: May 8, 2015

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Area of Science:

Biomaterials Science
Nanotechnology
Molecular Biology

Background:

Traditional DNA block copolymers typically form simple spherical micelles.
Developing novel self-assembling nanostructures with tunable morphologies is crucial for advanced applications.

Purpose of the Study:

To design and fabricate unusual low-dimensional DNA nanostructures using programmable peptide interactions.
To explore the self-assembly behavior of dual-bioactive DNA-block-poly(amino acid) copolymers.

Main Methods:

Synthesis of DNA-block-poly(amino acid) copolymers by coupling oligonucleotides to phenylalanine-based polymers.
Investigation of self-assembly into various low-dimensional structures (nanofibers, ribbons, sheets).
Analysis of protease-induced shape transformations in the DNA assemblies.

Main Results:

DNA-block-poly(amino acid) copolymers self-assembled into diverse low-dimensional structures, unlike spherical micelles formed by typical DNA block copolymers.
Controllable amino acid interactions directed the formation of nanofibers, ribbons, and sheets.
Protease treatment induced shape transformations from fiber to sheet morphologies, dependent on enzyme type and amino acid sequence.

Conclusions:

Peptide-based self-assembly offers a programmable route to engineer dynamic DNA assemblies with unusual low-dimensional morphologies.
This approach enables the fabrication of diverse and controllable nanostructures for potential applications in materials science and nanotechnology.