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Updated: Dec 30, 2025

Using a Murine Model of Psychosocial Stress in Pregnancy as a Translationally Relevant Paradigm for Psychiatric Disorders in Mothers and Infants
Published on: June 13, 2021
Postpartum stress and infant outcome: A review of current literature
Aderonke Oyetunji1, Prakash Chandra1
1Department of Psychiatry/Child and Adolescent Psychiatry, Truman Medical Centers, 2301 Holmes St, Kansas City, MO 64108, USA.
Insights
Postpartum stress negatively impacts infant growth, development, and sleep. Early identification and intervention are crucial for mitigating these adverse effects on infant wellbeing.
Area of Science:
- Perinatal mental health
- Infant development
- Maternal-infant attachment
Background:
- Postpartum stress is linked to adverse infant outcomes.
- Chronic or persistent stress can negatively affect infant growth, feeding, sleep, and development.
- Understanding these effects is vital for early intervention.
Purpose of the Study:
- To define the physical and functional effects of postpartum stress on infant mental wellbeing.
- To systematically review existing literature on the association between postpartum stress and infant outcomes.
- To identify key areas of impact for targeted research and support.
Main Methods:
- Systematic review of English language articles (1995-2019).
- Searched PubMed, Medline, and Psych base databases using keywords: postpartum, stress, infant, growth, development, nutrition, attachment, sleep.
- Included qualitative and quantitative human studies; excluded animal studies and those with women on medication.
Main Results:
- Postpartum stress is negatively associated with infant growth, leading to stunting.
- It correlates with poor language, cognitive, and motor development, and disrupted infant sleep.
- An inverse relationship exists between breastfeeding and postpartum depression; maternal age is linked to decreased maternal-infant attachment.
Conclusions:
- Postpartum stress significantly impacts infant development, growth, feeding, and sleep.
- Maternal age and breastfeeding efficacy are identified as mediating factors.
- Further research is needed to understand and mitigate the impact of modifiable factors.
Abstract:
Postpartum stress has been shown to have an association with infant growth, nutrition, bonding, temperament and ultimately childhood mental wellbeing. When persistent, recurring or chronic, it can negatively impact infant outcome, including the subscales of mental wellbeing such as growth, development, feeding, attachment and sleep. This study aims to define the physical and functional effect of postpartum stress on measures of infant mental wellbeing. A systematic review of English language articles published between 1995 and 2019 on PubMed, Medline and Psych base databases was carried out. Search terms used included postpartum, stress, infant, growth, development, nutrition, attachment and sleep. Both qualitative and quantitative studies were reviewed with eligibility criteria. Inclusion criteria of human studies, mothers diagnosed with depressive and anxiety symptoms postpartum with infant correlates were used. All animal studies and studies with women already on medication were excluded. A total of 74 articles were reviewed and summarized into postpartum stress associations with infant growth, development, nutrition, sleep and maternal fetal attachment. Postpartum stress is negatively associated with poor developmental trajectories and linear growth deficits, causing stunting in growth; poor language and cognitive development; poor gross and fine motor movement, and infant sleep. An inverse relationship exists with breast feeding and postpartum depression. More importantly, breastfeeding efficacy is important for sustaining positive infant feeding outcome. Increased maternal age during postpartum depression has been linked, as a contributing factor, to decreased maternal fetal attachment/bonding. A ripple effect exists from the association between postpartum stress and poor infant sleep. There is strong evidence that correlates PPS to infant outcome, mediated through many external factors. More research needs to be conducted to delineate and potentially mitigate the impact of modifiable factors. Not all articles in the literature were reviewed.
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