Short-term effect of PM₁ on hospital admission for ischemic stroke: A multi-city case-crossover study in China

This study aims to examine the association between short-term exposures to PM₁, PM_2.5 and PM₁₀ (particulate matter with aerodynamic diameters ≤1 μm, ≤2.5 μm and ≤10 μm, respectively) and hospital admission for ischemic stroke in China. Daily counts of hospital admission for ischemic stroke were collected in 5 hospitals in China during November 2013 to October 2015. Daily concentrations of PM₁, PM_2.5 and PM₁₀ were collected in 5 cities where the hospitals were located. A time-stratified case-crossover design was used to examine the hospital-specific PM-ischemic stroke association after controlling for potential confounders. Then the effect estimates were pooled using a random-effect meta-analysis. A total of 68,122 hospital admissions for ischemic stroke were identified from 5 hospitals during the study period. The pooled results showed that exposures to PM₁, PM_2.5 and PM₁₀ were significantly associated with increased hospital admission for ischemic stroke on the current day and previous 1 day. The RRs (relative risk associated with per 10 μg/m³ increase in each pollutant) and 95%CIs (confidence intervals) for the cumulative effects of PM₁, PM_2.5 and PM₁₀ on ischemic stroke during lag 0-1 days were 1.014 (1.005, 1.0023), 1.007 (1.000, 1.014) and 1.005 (1.001, 1.009), respectively. In total, 3.5%, 3.6% and 4.1% of hospital admissions for ischemic stroke could be attributable to PM₁, PM_2.5 and PM₁₀, respectively. Exposures to ambient PM₁, PM_2.5 and PM₁₀ pollution showed acute adverse effects on hospital admission for ischemic stroke. The health effects of PM₁ should be considered by policy-makers.