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Updated: Dec 30, 2025
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Translational Orthotopic Models of Glioblastoma Multiforme
Published on: February 17, 2023
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Malignant "Angioglioma": Clinical, Radiologic, and Histopathologic Features
Thomas Linsenmann1, Thomas Westermaier1, Camelia Monoranu2
1Department of Neurosurgery, University Hospital Wuerzburg, Wuerzburg, Germany.
Summary
The rare co-occurrence of glioblastoma multiforme (GBM) and arteriovenous malformations (AVMs) in the brain is challenging to diagnose due to varied presentations. Tumor activity may contribute to AVM development.
Area of Science:
- Neuro-oncology
- Vascular neurosurgery
- Neuropathology
Background:
- Glioblastoma multiforme (GBM) is the most common primary malignant brain tumor in adults.
- Arteriovenous malformations (AVMs) are congenital vascular anomalies, often presenting with hemorrhage.
- Previous literature describes associations between AVMs and low-grade gliomas (angiogliomas) and also GBMs.
Observation:
- This study reports on four patients with coincident GBM and AVM in the same brain location.
- Data collected from 2006-2014 included patient presentation, clinical findings, tumor location, and histopathology.
- All patients underwent surgical intervention for their conditions.
Findings:
- The simultaneous occurrence of cerebral AVM and GBM is exceptionally rare, with limited case reports available.
- Clinical and radiological presentations of these coincident cases are highly variable and individualized.
- Proangiogenic factors are hypothesized to play a role in the simultaneous development of both pathologies.
Implications:
- The pathogenesis of AVMs in proximity to GBMs may be influenced by tumor-derived proangiogenic factors.
- Pathologic vessels are a known feature of malignant gliomas, suggesting a potential role in vascular malformation development.
- Further research is needed to elucidate the complex relationship between GBMs and AVMs.
