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Updated: Dec 30, 2025

Synthesis of Information-bearing Peptoids and their Sequence-directed Dynamic Covalent Self-assembly
Published on: February 6, 2020
Assembly of heteropolymers via a network of reaction coordinates
Davide Chiuchiù1, James Ferrare1,2, Simone Pigolotti1
1Biological Complexity Unit, Okinawa Institute for Science and Technology, 1919-1 Tancha, Onna, Kunigami-gun, Okinawa 904-0412, Japan.
Abstract:
In biochemistry, heteropolymers encoding biological information are assembled out of equilibrium by sequentially incorporating available monomers found in the environment. Current models of polymerization treat monomer incorporation as a sequence of discrete chemical reactions between intermediate metastable states. In this paper, we use ideas from reaction rate theory and describe nonequilibrium assembly of a heteropolymer via a continuous reaction coordinate. Our approach allows for estimating the copy error and incorporation speed from the Gibbs free energy landscape of the process. We apply our theory to several examples from a simple reaction characterized by a free energy barrier to more complex cases incorporating error correction mechanisms, such as kinetic proofreading.
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