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The structure of the human glutathione S-transferase pi gene
I G Cowell1, K H Dixon, S E Pemble
1Cancer Research Campaign Molecular Toxicology Research Group, University College and Middlesex School of Medicine, London, U.K.
The Biochemical Journal
|October 1, 1988
Abstract:
The human glutathione S-transferase pi gene has been isolated from a cosmid library. The gene spans approximately 3 kb, is interrupted by six introns and the region around its 5' end has the high G + C and CpG content typical of an HTF (HpaII tiny fragment) island. In addition to a TATA box at position -28 relative to the transcription initiation site and two G + C boxes (GGGCGG), the promoter contains a sequence motif matching the phorbol ester- and ras-responsive element from the polyoma virus enhancer.