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Updated: Dec 30, 2025

Polyelectrolyte Complex for Heparin Binding Domain Osteogenic Growth Factor Delivery
Published on: August 22, 2016
The Challenge of Modulating Heparan Sulfate Turnover by Multitarget Heparin Derivatives
Noemi Veraldi1, Nawel Zouggari2, Ariane de Agostini3
1Division of Clinical Pathology, Department of Diagnostics, Geneva University Hospitals, 1211 Geneva 14, Switzerland.
Abstract:
This review comes as a part of the special issue "Emerging frontiers in GAGs and mimetics". Our interest is in the manipulation of heparan sulfate (HS) turnover by employing HS mimetics/heparin derivatives that exert pleiotropic effects and are interesting for interfering at multiple levels with pathways in which HS is implicated. Due to the important role of heparanase in HS post-biosynthetic modification and catabolism, we focus on the possibility to target heparanase, at both extracellular and intracellular levels, a strategy that can be applied to many conditions, from inflammation to cancer and neurodegeneration.
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