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Updated: Dec 30, 2025

Murine Dermal Fibroblast Isolation by FACS
Published on: January 7, 2016
Scars or Regeneration?-Dermal Fibroblasts as Drivers of Diverse Skin Wound Responses
Dongsheng Jiang1, Yuval Rinkevich1
1Comprehensive Pneumology Center, Institute of Lung Biology and Disease, Helmholtz Zentrum München, Max-Lebsche-Platz 31, 81377 Munich, Germany.
Abstract:
Scarring and regeneration are two physiologically opposite endpoints to skin injuries, with mammals, including humans, typically healing wounds with fibrotic scars. We aim to provide an updated review on fibroblast heterogeneity as determinants of the scarring-regeneration continuum. We discuss fibroblast-centric mechanisms that dictate scarring-regeneration continua with a focus on intercellular and cell-matrix adhesion. Improved understanding of fibroblast lineage-specific mechanisms and how they determine scar severity will ultimately allow for the development of antiscarring therapies and the promotion of tissue regeneration.
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