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Updated: Dec 30, 2025

Assays for Validating Histone Acetyltransferase Inhibitors
Published on: August 6, 2020
Anticancer RuII and RhIII Piano-Stool Complexes that are Histone Deacetylase Inhibitors
Jasmine M Cross1, Tim R Blower2, Natalie Gallagher3
1Department of Chemistry, Durham University, South Road, Durham, DH1 3LE, United Kingdom.
Abstract:
The first examples of RuII and RhIII piano-stool complex histone deacetylase (HDAC) inhibitors are presented. The novel complexes have antiproliferative activity against H460 non-small-cell lung carcinoma cells that is comparable to the clinically used HDAC inhibitor suberoylanilide hydroxamic acid (SAHA). Strong evidence for HDAC inhibition as a primary mechanism of action is provided. The complexes reported here represent an important step towards the design of highly active and selective HDAC inhibitors.
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