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Application of γ-Valerolactone as an Alternative Biomass-Based Medium for Aminocarbonylation Reactions
Diána Marosvölgyi-Haskó1,2, Blanka Lengyel3, József M Tukacs3
1Department of Inorganic Chemistry, University of Pécs, János Szentágothai Research Center, MTA-PTE Research Group for Selective Chemical Syntheses, Ifjúság u. 6., 7624, Pécs, Hungary.
Abstract:
γ-Valerolactone (GVL) was proposed as a renewable, nontoxic reaction medium with negligible vapor pressure for homogeneous Pd-catalyzed aminocarbonylation reactions. Iodobenzene as a model substrate and its 4-substituted derivatives were converted to the corresponding 2-ketocarboxamides with high conversions and chemoselectivities in γ-valerolactone. The effect of carbon monoxide pressure and reaction temperature on the conversion and selectivities were studied in the range 1-50 bar and 25-100 °C, respectively. The highest conversion and selectivity was achieved at 25 bar and 50 °C for iodobenzene in GVL for 24 h.
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