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Investigating von Willebrand Factor Pathophysiology Using a Flow Chamber Model of von Willebrand Factor-platelet String Formation
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Elevated Plasma von Willebrand Factor Antigen and Activity Levels Are Associated With the Severity of Coronary

Bin Yan1, Qi Wang2, Weipeng Du1

  • 1Department of Clinical Laboratory Medicine, Nanyang Central Hospital, Nanyang, China.

Clinical and Applied Thrombosis/Hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis
|January 23, 2020
PubMed

Insights

Elevated levels of von Willebrand factor (VWF) antigen and VWF-collagen binding correlate with coronary artery disease severity in acute myocardial infarction patients. VWF screening may predict stenosis extent.

Area of Science:

  • Cardiovascular Medicine
  • Hematology
  • Biochemistry

Background:

  • von Willebrand factor (VWF) is critical in platelet aggregation and vascular injury.
  • Coronary artery disease (CAD) and its acute complication, acute myocardial infarction (AMI), involve complex hemostatic mechanisms.
  • The role of VWF in quantifying coronary stenosis severity in AMI patients requires further elucidation.

Purpose of the Study:

  • To investigate the association between plasma VWF antigen (VWF: Ag) and VWF-collagen binding (VWF: CB) levels and the severity of coronary stenosis in patients with AMI.
  • To determine if VWF levels are independent predictors of coronary stenosis severity, as quantified by the Gensini score.

Main Methods:

  • Plasma VWF: Ag and VWF: CB levels were measured in 205 AMI patients and 123 healthy controls.
  • AMI patients were stratified based on Gensini scores to assess coronary stenosis severity.
  • Statistical analyses were performed to correlate VWF levels with Gensini scores and the number of affected coronary vessels, adjusting for confounding factors.

Main Results:

  • Patients with AMI exhibited significantly higher VWF: Ag and VWF: CB levels compared to controls (P < .001).
  • Both VWF: Ag and VWF: CB levels showed a positive correlation with the Gensini score and the number of diseased coronary vessels.
  • VWF: Ag and VWF: CB were identified as independent factors associated with coronary stenosis severity.

Conclusions:

  • Plasma VWF: Ag and VWF: CB levels are positively correlated with the severity of coronary stenosis in AMI patients.
  • VWF measurements at the time of AMI may offer prognostic value regarding the extent of coronary artery disease.
  • These findings highlight VWF as a potential biomarker for assessing CAD severity in the context of AMI.

Keywords:
acute myocardial infarctioncollagencoronary stenosisrisk factorsvon Willebrand factor

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