Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Routes of Drug Administration: Overview01:22

Routes of Drug Administration: Overview

9.0K
Drug administration involves delivering drugs to the body through various routes, such as enteral, parenteral, and topical.
Enteral administration refers to drugs absorbed through the gastrointestinal tract. They can be swallowed (perorally), placed under the tongue (sublingually), or on the inner lining of the cheeks (buccally). Perorally administered drugs take time to be absorbed and have a slower onset of action. The rectal route is another form of enteral administration, which allows for...
9.0K
Dosage Regimen: Multiple Oral Dosage01:25

Dosage Regimen: Multiple Oral Dosage

178
Understanding how a drug's concentration fluctuates within the body over time is crucial in pharmacokinetics, particularly with multiple oral doses. A graphical representation of multiple oral dosages provides insight into these dynamics. Typical accumulation curves of a drug's concentration in the body reveal a sawtooth pattern, indicating periodic peaks and troughs correlating with each dose administration and the drug's subsequent elimination.The plasma concentration at any time during an...
178
Drug Dosage Regimen: Overview01:15

Drug Dosage Regimen: Overview

4.3K
A drug dosage regimen describes the specific instructions and schedule for administering a drug to a patient. It considers factors such as drug dosage, frequency, route of administration, and duration of treatment. Designing an appropriate dosage regimen for a patient aims to achieve a target drug concentration at the site of action.
Typically, the starting dose and dosing interval are guided by the manufacturer's recommendations based on clinical trials conducted during and after drug...
4.3K
Drug Administration and Therapy Phases: Overview01:26

Drug Administration and Therapy Phases: Overview

1.1K
Drugs, the chemical agents used in diagnosing, treating, or preventing diseases, undergo a four-phase process of development: pharmaceutic, pharmacokinetics, pharmacodynamics, and therapeutic.
The pharmaceutical phase focuses on leveraging the physicochemical properties of the drug to design and manufacture an effective product. Variants include orally administered tablets or capsules, topical creams or ointments, and parenteral-delivery solutions or emulsions.
The pharmacokinetic phase...
1.1K
Drug Accumulation During Multiple Dosing: Intermittent IV Infusions01:24

Drug Accumulation During Multiple Dosing: Intermittent IV Infusions

182
Intermittent intravenous (IV) infusion is a method of drug administration where medications are delivered over short infusion periods followed by intervals of no drug delivery. This approach helps to prevent sustained high drug concentrations in the bloodstream, reducing the risk of adverse effects associated with prolonged exposure. Unlike continuous infusion, steady-state concentrations may not be achieved during a single dosing cycle but can be reached through repeated...
182
Subviral Agents01:29

Subviral Agents

407
Subviral agents are infectious entities that resemble viruses but lack one or more viral components, such as a capsid or essential replication machinery. These agents include viroids, prions, and satellites, each possessing distinct structural and functional characteristics that influence their mode of infection and replication.Viroids are the simplest subviral agents, consisting of circular, single-stranded RNA molecules without a protein coat. They exclusively infect plants, relying entirely...
407

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Systematic review of growth factors and cytokines for the management of oral mucositis in cancer patients and clinical practice guidelines.

Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer·2020
Same author

Antioxidant and antiatherogenic effects of pomegranate.

American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists·2011
Same journal

Performance evaluation of a two-arm robotic chemotherapy compounding system: Effects of syringe size and compounding cycles on accuracy, efficiency, and safety margins.

Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners·2026
Same journal

Impact of community pharmacy-based telephone follow-up on treatment completion in cancer patients receiving adjuvant chemotherapy: A retrospective observational study.

Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners·2026
Same journal

Polypharmacy and clinical outcomes in geriatric patients with metastatic hormone-sensitive prostate cancer treated with androgen receptor pathway inhibitors.

Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners·2026
Same journal

Therapeutic potential of aspirin in metastatic brain disease: A narrative review bridging evidence from systemic cancers to brain metastasis.

Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners·2026
Same journal

Incidence of neutropenia with intrathecal pemetrexed for leptomeningeal disease associated with solid tumors - A retrospective analysis.

Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners·2026
Same journal

Bridging the pain gaps: Opioid access for cancer pain in rural Nepal and the untapped role of pharmacists.

Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners·2026
See all related articles

Related Experiment Video

Updated: Dec 30, 2025

Transarterial Administration of Oncolytic Viruses for Locoregional Therapy of Orthotopic HCC in Rats
08:55

Transarterial Administration of Oncolytic Viruses for Locoregional Therapy of Orthotopic HCC in Rats

Published on: April 15, 2016

9.8K

Administration sequence for multi-agent oncolytic regimens.

Alga S Ramos Morales1, Jamie K Joy1, Daniela M Zbona2

  • 1Cancer Treatment Centers of America Global, Boca Raton, FL, USA.

Journal of Oncology Pharmacy Practice : Official Publication of the International Society of Oncology Pharmacy Practitioners
|January 23, 2020
PubMed
Summary
This summary is machine-generated.

Establishing optimal sequencing for combination cancer therapies is crucial for patient safety and efficient workflows. This guideline provides clear drug administration order recommendations for oncology providers.

Keywords:
Administrationchemotherapyoncologyoncolyticsequence

More Related Videos

Genome-wide RNAi Screening to Identify Host Factors That Modulate Oncolytic Virus Therapy
08:51

Genome-wide RNAi Screening to Identify Host Factors That Modulate Oncolytic Virus Therapy

Published on: April 3, 2018

9.4K
Paramyxoviruses for Tumor-targeted Immunomodulation: Design and Evaluation Ex Vivo
12:42

Paramyxoviruses for Tumor-targeted Immunomodulation: Design and Evaluation Ex Vivo

Published on: January 7, 2019

10.0K

Related Experiment Videos

Last Updated: Dec 30, 2025

Transarterial Administration of Oncolytic Viruses for Locoregional Therapy of Orthotopic HCC in Rats
08:55

Transarterial Administration of Oncolytic Viruses for Locoregional Therapy of Orthotopic HCC in Rats

Published on: April 15, 2016

9.8K
Genome-wide RNAi Screening to Identify Host Factors That Modulate Oncolytic Virus Therapy
08:51

Genome-wide RNAi Screening to Identify Host Factors That Modulate Oncolytic Virus Therapy

Published on: April 3, 2018

9.4K
Paramyxoviruses for Tumor-targeted Immunomodulation: Design and Evaluation Ex Vivo
12:42

Paramyxoviruses for Tumor-targeted Immunomodulation: Design and Evaluation Ex Vivo

Published on: January 7, 2019

10.0K

Area of Science:

  • Oncology
  • Pharmacology
  • Clinical Pharmacy

Background:

  • Combination chemotherapy regimens require defined administration sequences.
  • Lack of standardized sequencing poses risks to patient safety and healthcare workflows.

Purpose of the Study:

  • To establish clear guidelines for the administration sequence of combination oncology drug regimens.
  • To support Pharmacy and Infusion Nursing in optimizing patient care and workflows.

Main Methods:

  • A comprehensive literature search identified drug administration sequencing instructions.
  • Regimens were prioritized based on clinical pathways, provider inquiries, and frequency of use.
  • Stratification by tumor type and alphabetical arrangement by indication facilitated organization.

Main Results:

  • A table of supporting literature for recommended drug sequences was compiled.
  • Institutional decisions, guided by expert recommendations, addressed gaps in literature.
  • Key principles included prioritizing vesicant/biologic agents first, taxanes before platinum agents, and shorter infusion durations.

Conclusions:

  • This guideline offers recommendations for oncology drug administration sequencing.
  • The guidance aims to improve patient safety and operational efficiency.
  • Ongoing review will incorporate additional regimens and sequencing recommendations.