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Impact of left ventricular diastolic dysfunction on long-term outcome in patients with lower extremity artery disease

Koji Yanaka1, Hirokuni Akahori1, Takahiro Imanaka1

  • 1Department of Cardiovascular and Renal Medicine, Hyogo College of Medicine, 1-1 Mukogawa-cho, Nishinomiya, Hyogo 663-8501, Japan.

Journal of Cardiology
|January 23, 2020
PubMed

Insights

Left ventricular diastolic dysfunction significantly increases the risk of major adverse cardiac and cerebrovascular events in patients with lower extremity artery disease. This finding highlights the importance of assessing diastolic function in LEAD patients for improved long-term outcomes.

Area of Science:

  • Cardiology
  • Vascular Medicine
  • Echocardiography

Background:

  • Lower extremity artery disease (LEAD) is a significant cardiovascular risk factor.
  • The impact of left ventricular (LV) diastolic dysfunction on long-term outcomes in LEAD patients remains understudied.
  • Understanding this relationship is crucial for comprehensive patient management.

Purpose of the Study:

  • To investigate the association between LV diastolic dysfunction and long-term outcomes in patients with LEAD.
  • To determine if LV diastolic dysfunction is an independent predictor of major adverse cardiac and cerebrovascular events (MACCE) in this population.

Main Methods:

  • A cohort of 200 LEAD patients with preserved LV systolic function was analyzed.
  • Patients were classified based on the presence or absence of LV diastolic dysfunction using established echocardiographic guidelines.
  • The 3-year cumulative incidence of MACCE (death, heart failure hospitalization, myocardial infarction, stroke) was compared between groups.

Main Results:

  • LV diastolic dysfunction was present in 31% of the studied LEAD patients.
  • The 3-year incidence of MACCE was significantly higher in patients with LV diastolic dysfunction (35%) compared to those without (23%).
  • Multivariate analysis identified LV diastolic dysfunction (HR=1.96) and critical limb ischemia (HR=2.52) as independent predictors of MACCE.

Conclusions:

  • LV diastolic dysfunction is a significant independent predictor of adverse cardiovascular and cerebrovascular events in patients with LEAD.
  • These findings underscore the importance of evaluating LV diastolic function in LEAD patients for risk stratification and improved clinical outcomes.
Abstract

Keywords:
Left ventricular diastolic dysfunctionLower extremity artery diseaseMajor cardiac and cerebrovascular events

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