Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Dementia01:30

Dementia

459
Dementia is a collective term for cognitive disorders primarily affecting memory, thinking, and reasoning. It is not a specific disease but a syndrome, with Alzheimer's disease being the most common cause, accounting for approximately 60-80% of cases. Other types include vascular dementia, Lewy body dementia, and frontotemporal dementia. Dementia affects millions worldwide, particularly older adults, though it is not a normal part of aging.
The progression of dementia is generally gradual....
459
Alzheimer's Disease: Treatment01:22

Alzheimer's Disease: Treatment

707
Alzheimer's Disease (AD), a neurodegenerative disorder, is pathologically identified by amyloid plaques and neurofibrillary tangles composed of tau protein. AD pharmacotherapy aims to manage cognitive symptoms, delay disease progression, and treat behavioral symptoms. The treatment is primarily symptomatic and palliative, with no definitive disease-modifying therapy available. Cholinesterase inhibitors, including donepezil (Aricept), rivastigmine (Exelon), and galantamine (Razadyne), are...
707
Parkinson's Disease: Treatment01:24

Parkinson's Disease: Treatment

886
Neurodegenerative disorders, such as Parkinson's Disease (PD), involve the gradual and irreversible destruction of neurons in particular brain areas. These disorders exhibit standard features like proteinopathies, selective vulnerability of some neurons, and an interaction of intrinsic properties, genetics, and environmental influences in neural injury.
Parkinson's Disease is primarily a result of the loss of dopaminergic neurons in the substantia nigra pars compacta. The cornerstone of...
886
Exercise and Cardiovascular Response01:20

Exercise and Cardiovascular Response

3.8K
Exercise significantly impacts cardiovascular response, which is crucial for understanding patient health and designing effective treatment plans.
Light to moderate physical activity initiates a series of interconnected responses in the body. The heart rate modestly increases in anticipation of the workout, followed by widespread vasodilation as oxygen consumption by skeletal muscles increases. This results in decreased peripheral resistance, increased capillary blood flow, and accelerated...
3.8K
Alzheimer's Disease: Overview01:26

Alzheimer's Disease: Overview

1.5K
Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
1.5K
Exercise and Cardiac Output01:17

Exercise and Cardiac Output

1.7K
Regular physical activity is essential for maintaining cardiovascular health, with aerobic exercises being particularly effective. According to the American Heart Association, 150 minutes of moderate to intense aerobic exercise per week is recommended for a healthy heart. Aerobic activities may include brisk walking, running, bicycling, cross-country skiing, and swimming, ideally performed three to five times per week.
Sustained exercise increases the muscles' oxygen demand, which can be...
1.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Dementia Education for Physiotherapy Students: A Questionnaire of Australian and Canadian Entry-to-Professional Practice Programmes.

Physiotherapy Canada. Physiotherapie Canada·2026
Same author

Handwriting patterns in isolated rapid eye movement sleep behaviour disorder.

Journal of Parkinson's disease·2026
Same author

Smartphone self-testing of hand and speech motor functions: a study of reliability and usability in older adults.

GeroScience·2025
Same author

Association of tongue, handgrip, and pinch strength with blood-based phosphorylated-tau 181 in cognitively healthy older adults.

GeroScience·2025
Same author

Falling short on implementation of fall prevention guidelines in health services: a systematic review with meta-analysis.

Age and ageing·2025
Same author

Advice to people with Parkinson's in my clinic: How to manage running-induced dystonia.

Journal of Parkinson's disease·2025
Same journal

Who I am affects what I do.

Practical neurology·2026
Same journal

Recurrent falls while taking clozapine.

Practical neurology·2026
Same journal

Anti-Ma2 encephalitis: when the examination localises beyond MRI.

Practical neurology·2026
Same journal

Oculopharyngeal muscular dystrophy: diagnosis, management and multisystem care.

Practical neurology·2026
Same journal

Neurological signs of possible diagnostic value in the cognitive clinic: past, present and future.

Practical neurology·2026
Same journal

Longitudinally extensive myelitis in neurosarcoidosis.

Practical neurology·2026
See all related articles

Related Experiment Video

Updated: Dec 30, 2025

Getting to Compliance in Forced Exercise in Rodents: A Critical Standard to Evaluate Exercise Impact in Aging-related Disorders and Disease
10:19

Getting to Compliance in Forced Exercise in Rodents: A Critical Standard to Evaluate Exercise Impact in Aging-related Disorders and Disease

Published on: August 22, 2014

14.6K

Exercise and dementia prevention.

Jane Alty1, Maree Farrow2, Katherine Lawler2

  • 1Wicking Dementia Research and Education Centre, College of Health and Medicine, University of Tasmania, Hobart, Tasmania, Australia jane.alty@utas.edu.au.

Practical Neurology
|January 23, 2020
PubMed
Summary
This summary is machine-generated.

Physical inactivity is a major modifiable risk factor for dementia. Regular exercise can positively influence cognition and reduce the risk of age-related cognitive decline and dementia.

Keywords:
Alzheimer’sdementiaexercisephysical activityrisk reduction

More Related Videos

Orienteering as a Tool for Cognitive Research: An Implementation Guide
07:13

Orienteering as a Tool for Cognitive Research: An Implementation Guide

Published on: November 29, 2024

1.4K
Exergaming in Older People Living with HIV Improves Balance, Mobility and Ameliorates Some Aspects of Frailty
07:27

Exergaming in Older People Living with HIV Improves Balance, Mobility and Ameliorates Some Aspects of Frailty

Published on: October 6, 2016

10.6K

Related Experiment Videos

Last Updated: Dec 30, 2025

Getting to Compliance in Forced Exercise in Rodents: A Critical Standard to Evaluate Exercise Impact in Aging-related Disorders and Disease
10:19

Getting to Compliance in Forced Exercise in Rodents: A Critical Standard to Evaluate Exercise Impact in Aging-related Disorders and Disease

Published on: August 22, 2014

14.6K
Orienteering as a Tool for Cognitive Research: An Implementation Guide
07:13

Orienteering as a Tool for Cognitive Research: An Implementation Guide

Published on: November 29, 2024

1.4K
Exergaming in Older People Living with HIV Improves Balance, Mobility and Ameliorates Some Aspects of Frailty
07:27

Exergaming in Older People Living with HIV Improves Balance, Mobility and Ameliorates Some Aspects of Frailty

Published on: October 6, 2016

10.6K

Area of Science:

  • Neurology
  • Gerontology
  • Public Health

Background:

  • Ageing, genetics, medical conditions, and lifestyle choices significantly influence dementia risk.
  • Approximately one-third of dementia cases are linked to modifiable factors like physical inactivity, smoking, and hypertension.
  • The increasing prevalence of dementia and the absence of effective neuroprotective drugs necessitate a focus on lifespan dementia prevention.

Observation:

  • Neurologists frequently advise patients with dementia risk factors on potential lifestyle modifications.
  • Exercise is increasingly recognized as a crucial intervention for enhancing cognitive function.
  • Physical activity plays a role in mitigating age-related cognitive decline and dementia risk.

Findings:

  • Physical inactivity represents a significant, modifiable risk factor for dementia.
  • Evidence supports exercise as a strategy to positively impact cognition.
  • Lifestyle interventions, particularly physical activity, are vital for dementia risk reduction.

Implications:

  • Neurologists can leverage evidence on physical inactivity to guide patients towards dementia risk reduction strategies.
  • Promoting exercise and addressing physical inactivity are key components of public health initiatives for cognitive aging.
  • Further research into the mechanisms linking physical activity to cognitive health is warranted for developing targeted interventions.