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Supplemental insulin delivery from an implanted reservoir activated by external compression
P Y Wang1, M C Lee, D M Shelton
1Institute of Biomedical Engineering, Faculty of Medicine, University of Toronto, Ontario, Canada.
ASAIO Transactions
|July 1, 1988
Summary
This study developed a novel implantable device for delivering insulin to diabetic rats, providing a daily dose for up to 24 days. The device offers a potential solution for managing blood glucose levels in diabetes management.
Area of Science:
- Biomaterials Science
- Endocrinology
- Drug Delivery Systems
Background:
- Hyperglycemia in diabetes necessitates effective insulin delivery.
- Existing insulin implants offer basal but not preprandial dosing.
- A new device is needed for flexible insulin administration.
Purpose of the Study:
- To design and evaluate a novel implantable device for percutaneous insulin delivery.
- To assess the duration and efficacy of insulin release from the device in diabetic rats.
- To investigate the potential for refilling the device for sustained insulin delivery.
Main Methods:
- An implantable device was constructed using foam, compressed insulin, and tetracycline, enclosed by membranes.
- The device was implanted subcutaneously in diabetic rats.
- Insulin release was triggered by serous fluid entering the device.
- Daily compression was applied to facilitate insulin delivery.
- Blood glucose levels were monitored post-implantation.
Main Results:
- The implant provided a daily insulin dose for 24 +/- 4 days in diabetic rats.
- Blood glucose levels were maintained at 3.4 +/- 1.1 mmol/L for 6-8 hours daily.
- The device demonstrated potential for percutaneous refilling with insulin suspension.
Conclusions:
- The developed implantable device effectively delivers insulin for daily glycemic control in diabetic rats.
- The device offers a promising approach for managing diabetes through a refillable insulin delivery system.
- Further research may explore long-term efficacy and human clinical applications.