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A permanent arterial access system.

J A Magovern1, G A Prophet, W E Pae

  • 1Department of Surgery, Milton S. Hershey Medical Center, Pennsylvania State University, Hershey 17033.

ASAIO Transactions
|July 1, 1988
PubMed
Summary
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A novel arterial access system (AAS) provides reliable, long-term access for physiologic studies in animals with mechanical circulatory support. This implantable system eliminates repeated cannulation, showing no increased risk of infection or thrombosis.

Area of Science:

  • Biomedical Engineering
  • Cardiovascular Research
  • Surgical Innovation

Background:

  • Long-term survival with mechanical circulatory devices necessitates reliable arterial access.
  • Previous methods required repeated arterial cannulation, posing risks and challenges.

Purpose of the Study:

  • To introduce and evaluate a novel arterial access system (AAS) for long-term physiologic and pharmacologic studies.
  • To assess the safety and efficacy of the AAS in animals with mechanical circulatory support.

Main Methods:

  • The AAS, comprising a Silastic catheter in the internal mammary artery and a subcutaneous access well, was implanted during initial surgery.
  • The system was tested in six calves (three with total artificial hearts, three with ventricular assist devices) for a mean of 124 days.

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  • Patency was maintained with weekly heparin flushes; access was obtained via percutaneous needle puncture.

    • Main Results:

    • The AAS demonstrated reliable long-term arterial access (mean 124 days, range 20-323 days).
    • No AAS-related infections or thromboses occurred in any of the implanted devices.
    • Excellent arterial waveforms were consistently obtained upon puncture.

    Conclusions:

    • The novel arterial access system is simple to implant and provides reliable, long-term arterial access.
    • The AAS does not appear to increase the risk of infection or thrombosis in animals with mechanical circulatory support.
    • This system offers a significant advancement for research requiring continuous hemodynamic monitoring.