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Related Experiment Videos

Augmented hemoperfusion for hyperbilirubinemia.

B F Brian1, W J Dorson, V B Pizziconi

  • 1Department of Chemical, Bio and Materials Engineering, Arizona State University, Tempe 85287.

ASAIO Transactions
|July 1, 1988
PubMed
Summary
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Sodium benzoate enhances hemoperfusion treatment for hyperbilirubinemia by improving bilirubin removal rates. This biocompatible agent significantly boosts the effectiveness of coated activated charcoal in blood purification.

Area of Science:

  • Biomedical Engineering
  • Clinical Chemistry
  • Hematology

Background:

  • Hyperbilirubinemia is treated with exchange transfusions and phototherapy, but these methods have limitations.
  • Hemoperfusion using coated activated charcoal (CAC) shows low bilirubin removal due to strong albumin binding.
  • Novel biocompatible agents are needed to improve bilirubin detachment for enhanced hemoperfusion efficacy.

Purpose of the Study:

  • To investigate biocompatible chemical agents for selectively unbinding bilirubin prior to hemoperfusion.
  • To assess the efficacy of sodium benzoate in augmenting bilirubin removal by CAC.
  • To evaluate the impact of sodium benzoate on hemoperfusion performance in plasma and blood.

Main Methods:

  • Batch and flow tests were conducted using mock solutions, human plasma, and bovine plasma/blood.

Related Experiment Videos

  • Coated activated charcoal (CAC) was used as the adsorbent.
  • Sodium benzoate was added at varying concentrations (50 mM and 100 mM) to assess its effect on bilirubin removal.
  • Platelet aggregation was measured to evaluate biocompatibility.

    • Main Results:

    • Sodium benzoate significantly increased bilirubin removal, reaching 96% at 100 mM in mock solutions.
    • Pretreatment of CAC with sodium benzoate was necessary due to rapid adsorptive removal.
    • In plasma and blood, 100 mM sodium benzoate increased bilirubin removal by 25% (plasma) and 35% (blood).
    • A notable decrease in platelet aggregation was observed with sodium benzoate addition.

    Conclusions:

    • Sodium benzoate effectively enhances bilirubin removal during hemoperfusion with CAC.
    • This augmented hemoperfusion shows promise as a clinically attractive treatment for hyperbilirubinemia.
    • The reduction in platelet aggregation further supports the potential clinical utility of this method.