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Related Experiment Videos

Backfiltration: does it occur in membrane plasma separation?

G Smolik1, U Baurmeister, M Hampe

  • 1Nephrological Department of Medical Clinic I, University Munich, FRG.

ASAIO Transactions
|July 1, 1988
PubMed
Summary
This summary is machine-generated.

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Backfiltration, the movement of fluid into the blood compartment, occurs in membrane plasma separation, not just hemodialysis. This bypass flow poses a risk, as contaminants can reach the blood.

Area of Science:

  • Biomedical Engineering
  • Membrane Science
  • Renal Replacement Therapy

Background:

  • Backfiltration in hemodialysis is the movement of dialysate into the blood compartment.
  • This phenomenon is critical for understanding device safety in extracorporeal therapies.

Purpose of the Study:

  • To investigate the existence of backfiltration in membrane plasma separation.
  • To determine if plasma can move from the filtrate side to the blood compartment.

Main Methods:

  • Experimental investigation using hollow fiber devices.
  • Analysis of transmembrane pressure and blood side pressure drop.
  • Measurement of filtrate and module outlet pressures.

Main Results:

Related Experiment Videos

  • Evidence of plasma flow parallel to blood flow within hollow fibers.
  • Backfiltration of plasma from filtrate to blood compartment observed near the module end.
  • Offset in mean transmembrane pressure and reduced blood side pressure drop in permeable fibers confirmed bypass flow.

    • Conclusions:

    • Backfiltration is not limited to zero net filtration conditions and occurs during clinical use of membrane plasma separation devices.
    • The presence of bypass flow and backfiltration is a critical safety concern.
    • Contaminants or wash-out products from the membrane can potentially reach the blood compartment.