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Types of Toxins01:36

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Humans continually engage with an environment rich in potentially harmful chemicals. These are introduced to our bodies through inhalation, ingestion, or skin contact. These chemicals exist in various forms, such as air and environmental pollutants, agricultural chemicals, organic solvents, and heavy metals.
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Anticholinesterases, also known as cholinesterase inhibitors, work by blocking the breakdown of acetylcholine, leading to its accumulation in the synaptic cleft. This accumulation indirectly enhances both muscarinic and nicotinic actions. These agents are classified as reversible or irreversible based on their mechanism of action.     
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Halogenation of Alkenes02:46

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Halogenation is the addition of chlorine or bromine across the double bond in an alkene to yield a vicinal dihalide. The reaction occurs in the presence of inert and non-nucleophilic solvents, such as methylene chloride, chloroform, or carbon tetrachloride.
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Analysis of Organochlorine Pesticides in a Soil Sample by a Modified QuEChERS Approach Using Ammonium Formate
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Is Technical-Grade Chlordane an Obesogen?

Juliana F Silva1, Bruno P Moreira1, Luís Rato2

  • 1Department of Microscopy, Laboratory of Cell Biology, Institute of Biomedical Sciences Abel Salazar (ICBAS), University of Porto, P.O. Box 4050-313, Porto, Portugal.

Current Medicinal Chemistry
|January 23, 2020
PubMed
Summary

Obesogens, environmental chemicals disrupting metabolism, are linked to the obesity epidemic. Technical-grade chlordane, a persistent pollutant, shows potential obesogenic activity, posing a public health threat.

Keywords:
Obesityendocrine disruptorobesogensorganochlorinepersistent organic pollutanttechnical-grade chlordane

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Area of Science:

  • Environmental Health
  • Endocrinology
  • Toxicology

Background:

  • Obesity prevalence has tripled, becoming a major public health concern.
  • Obesogens, exogenous chemicals, are increasingly linked to obesity by disrupting metabolic processes and appetite.
  • Technical-grade chlordane is an environmental organochlorine pesticide and persistent organic pollutant.

Purpose of the Study:

  • To discuss the emerging role of obesogens as public health threats.
  • To highlight the environmental persistence of chlordane.
  • To examine chlordane's potential obesogenic activity as an endocrine disruptor.

Main Methods:

  • Literature review on obesogens and their link to metabolic disorders.
  • Analysis of chlordane's properties as a persistent organic pollutant.
  • Discussion of epidemiological and toxicological evidence regarding chlordane's effects.

Main Results:

  • Obesogens are exogenous compounds that can alter energy balance, appetite, and metabolism, contributing to weight gain.
  • Technical-grade chlordane is persistent in the environment and lipophilic, allowing storage in fat tissues.
  • Epidemiological studies associate persistent organic pollutants, including chlordane, with metabolic disorders like obesity.

Conclusions:

  • Obesogens represent a significant and emerging threat to public health.
  • Chlordane's environmental persistence and its endocrine-disrupting properties suggest potential obesogenic activity.
  • Further research is warranted to fully understand chlordane's impact on metabolic health and weight regulation.