Clinical experience with a new hemodiafiltration (HDF) system

Purity of reinfusion fluid and dialysate is mandatory in high flux, high efficiency substitutive treatments for chronic uremia, particularly when using bicarbonate concentrates. Bags of sterile and pyrogen free substitution fluid are in part responsible for the high costs of these treatments. In order to overcome these problems, the authors tested a new monitoring system (MPS-10, Gambro) for high efficiency hemodiafiltration (HDF) in which the reinfusion fluid was prepared from bicarbonate dialysate by filtration. During 5 months time, 96 on-line HDF treatments were performed in five chronic uremic patients. We found the infusion fluid and dialysate containing bicarbonate free from bacteria and endotoxins, with a correct weight balance obtained by the monitoring system. The authors believe that MPS-10 is a safe and adequate system for the production of sterile, pyrogen free dialysate and reinfusion fluid for on-line HDF, hemodialysis (HD), and hemofiltration (HF).