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Rifampin activity against Staphylococcus epidermidis biofilms
G Obst1, R F Gagnon, J Prentis
1Department of Medicine, Montreal General Hospital, McGill University, Quebec, Canada.
ASAIO Transactions
|July 1, 1988
Abstract:
Rifampin has demonstrated remarkable antimicrobial activity against Staphylococcus epidermidis biofilms. Four other antibiotics had no effect when used alone; three of these (clindamycin, gentamicin, and tetracycline) were antagonistic to rifampin when used in combination. Vancomycin was synergistic with rifampin, producing complete killing. Fresh peritoneal dialysis (PD) solution accentuated the antimicrobial activity, whereas spent PD fluid neutralized it.