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Updated: Dec 30, 2025
Predictive Immune Modeling of Solid Tumors
Published on: February 25, 2020
A meta-analysis: could we predict the malignancy of solid pseudopapillary neoplasm?
He Song1, Ming Dong1, Huimin Xiao2
1Department of Gastrointestinal Surgery, The First Hospital of China Medical University Shenyang 110001, China.
Objective:
To evaluate the risk factors influencing the malignant potential of solid pseudopapillary neoplasm (SPN).
Methods:
This meta-analysis used MEDLINE (PubMed), EMBASE and web of science including 14 cohort studies reporting the risk factors influencing the malignant potential after the initial operation on SPN up to March 2017. Review Manager Software 5.2 was used for meta-analysis.
Results:
14 studies with a total of 763 patients were included in our meta-analysis. In all the variables, age and tumor size were significantly correlated with malignancy.
Conclusion:
Malignant SPNs tended to be larger in diameter and younger in age than benign type. In particularly, larger tumor size may be a crucial factor for decision of aggressive resection.
