Association between ACE gene polymorphisms and Alzheimer's disease in Han population in Hebei Peninsula

This study aimed to detect the association between angiotensin I converting enzyme (ACE) gene polymorphisms (rs4343 and rs1800764) and Alzheimer's disease (AD) in Han population in Hebei Peninsular.

We recruited 113 AD patients and 142 healthy individuals in this case-control study. Differences of genotypes, alleles and haplotypes in two groups were analyzed by chi-square test. Besides, odds ratios (ORs) and 95% confidence intervals (CIs) were used to represent the relative risk of AD. At last, the analyses of linkage disequilibrium and haplotypes were done with HaploView software.

In the analyses of genotypes and alleles of ACE polymorphisms (rs4343 and rs1800764) in AD, no obvious association was found between genotypes and alleles of rs4343 with the susceptibility of AD. In rs1800764 polymorphism, only C allele had significant association with AD susceptibility (P=0.035, OR=1.473, 95% CI=1.027-2.111), which suggested that rs1800764 C allele is the susceptible allele of AD. Linkage disequilibrium analysis between rs4343 and rs1800764 polymorphisms indicated there existed 3 haplotypes (A-T, A-C and G-C). A-C haplotype might associate with the susceptibility of AD (P=0.023, OR=2.591, 95% CI=1.111-6.043).

Rs4343 polymorphism of ACE gene had no relationship with AD risk. C allele of rs1800764 could increase the susceptibility of AD. A-C haplotype of rs4343 and rs1800764 polymorphisms might increase the risk of AD, and the ORs was 2.591.