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IS MESENTERIC PANNICULITIS A SIGN FOR AUTOIMMUNE DIABETES IN ADULTS?

Evangelos C Rizos, Thalia Panagiotopoulou, Evangelos Liberopoulos

    AACE Clinical Case Reports
    |January 23, 2020
    PubMed
    Abstract

    Insights

    Mesenteric panniculitis (MP), a rare fibrosing disease, was observed in a patient with new-onset diabetes mellitus (DM). This case links MP to autoimmune DM, suggesting a potential new pathophysiological connection.

    Area of Science:

    • Gastroenterology
    • Endocrinology
    • Pathology

    Background:

    • Mesenteric panniculitis (MP) is a rare fibrosing inflammatory condition of the mesentery.
    • Diagnosis typically relies on imaging (CT/MRI) and biopsy.

    Observation:

    • A 48-year-old male presented with new-onset symptomatic diabetes mellitus (DM).
    • Abdominal CT revealed a mesenteric mass consistent with MP.
    • Initial DM treatment showed transient HbA1c improvement, followed by a rise and positive GAD auto-antibodies.

    Findings:

    • The patient was diagnosed with autoimmune DM, confirmed by auto-antibody presence.
    • This represents the first reported case correlating MP with autoimmune DM.

    Implications:

    • Suggests a potential link between MP and autoimmune DM.
    • Highlights the need to investigate autoimmune etiologies in patients with MP and DM.
    • Warrants further research into the pathophysiological mechanisms connecting these conditions.

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