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Cercosporin-Photocatalyzed [4+1]- and [4+2]-Annulations of Azoalkenes Under Mild Conditions
Published on: July 17, 2020
Isocadiolides A-H: Polybrominated Aromatics from a Synoicum sp. Ascidian
Jongkyoon Bae1, Eunji Cho2, Jae Sung Park1
1Natural Products Research Institute, College of Pharmacy , Seoul National University , San 56-1 , Sillim, Gwanak, Seoul 151-742 , Korea.
Abstract:
Isocadiolides A-H (1-8) and cadiolide N (9), new polybrominated aromatic compounds, were isolated from a Korean Synoicum sp. ascidian. On the basis of the results of extensive spectroscopic analyses, these compounds possessed tris-bromohydroxyphenyl moieties as a common structural motif, while their cores varied [cyclopentenedione (1-5), dihydrofuran (6 and 7), pyranone (8), and furanone (9)], reflecting different extents of rearrangement and oxidation. Several of these compounds exhibited weak antibacterial activities and moderate abilities to inhibit the microbial enzymes sortase A and isocitrate lyase.
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