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[Good practices for the use of biological tools in infectious diseases during pregnancy].

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Updated: Dec 30, 2025

Development of an IFN-γ ELISpot Assay to Assess Varicella-Zoster Virus-specific Cell-mediated Immunity Following Umbilical Cord Blood Transplantation
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Varicelle et grossesse.

Christelle Vauloup-Fellous1, Olivier Picone2

  • 1AP-HP, Hôpital Paul-Brousse, Groupe hospitalier universitaire Paris-Sud, Virologie, Centre national de référence pour les infections rubéoleuses maternofœtales, Université Paris-Sud, Inserm U1193, 94804 Villejuif, France.

Virologie (Montrouge, France)
|January 23, 2020
PubMed
Summary

Primary varicella (chickenpox) infection during pregnancy is rare but poses risks to mother, fetus, and newborn. Management involves diagnostic tools, prophylaxis, and antiviral treatments for pregnant women.

Keywords:
congenital neonatal varicellafetal varicella syndromepregnancyvaricellavaricella zoster virus

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Area of Science:

  • Obstetrics and Gynecology
  • Infectious Diseases
  • Pediatrics

Background:

  • Varicella-zoster virus (VZV) primary infection in pregnancy is uncommon in France.
  • While typically benign, VZV infection can lead to severe maternal, fetal, and neonatal complications.
  • Risks include maternal illness (especially in the third trimester), fetal varicella syndrome (if infection occurs before 20 weeks gestation), and congenital neonatal varicella (if maternal infection is peripartum.

Purpose of the Study:

  • To review the implications of primary varicella infection in pregnant women.
  • To outline available diagnostic, prophylactic, and therapeutic strategies for managing varicella during pregnancy.

Main Methods:

  • Literature review of varicella-zoster virus primary infection in pregnancy.
  • Analysis of diagnostic tools, prophylaxis, and antiviral treatments.

Main Results:

  • Maternal VZV infection poses significant risks depending on gestational age.
  • Fetal and neonatal complications are well-documented, including fetal varicella syndrome and congenital neonatal varicella.
  • Effective management strategies are available.

Conclusions:

  • Varicella in pregnancy requires careful consideration due to potential severe outcomes.
  • Early diagnosis, appropriate prophylaxis, and timely antiviral treatment are crucial for optimizing maternal and fetal health.
  • Clinicians and patients should be aware of the risks and management options.