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Updated: Dec 30, 2025
Detecting Amyloid-β Accumulation via Immunofluorescent Staining in a Mouse Model of Alzheimer's Disease
Published on: April 19, 2021
Ratiometric detection of amyloid-β aggregation by a dual-emissive tris-heteroleptic ruthenium complex
Jiang-Yang Shao1, Si-Hai Wu2, Junjie Ma2
1School of Medicine, Huaqiao University, Quanzhou, Fujian 362021, China. wusihai@hqu.edu.cn and Beijing National Laboratory for Molecular Sciences, CAS Key Laboratory of Photochemistry, CAS Research/Education Center for Excellence in Molecular Sciences, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China. zhongyuwu@iccas.ac.cn.
Abstract:
A dual-emissive tris-heteroleptic ruthenium complex is designed, synthesized and applied for the ratiometric photoluminescent detection of amyloid-β (Aβ) aggregation in both steady and transient states. The Aβ aggregation is supported by transmission electron microscopy and confocal laser scanning microscopy analysis. In addition, molecular docking calculations have been performed to gain insights into the interaction mode between the ruthenium complex and Aβ fibrils.
