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Cardiovascular risk factors and the concentration of asymmetric dimethylarginine

Paweł Gać1,2, Małgorzata Poręba3, Marta Jurdziak1

  • 1Department of Internal Medicine, Occupational Diseases and Hypertension, Wroclaw Medical University, Poland.

Advances in Clinical and Experimental Medicine : Official Organ Wroclaw Medical University
|January 23, 2020
PubMed

Insights

Elevated blood levels of asymmetric dimethylarginine (ADMA) correlate with an increased number of cardiovascular risk factors. This suggests ADMA may indicate higher cardiovascular risk, particularly with type 2 diabetes, hypertension, and hypercholesterolemia.

Area of Science:

  • Cardiovascular Medicine
  • Biochemistry
  • Clinical Research

Background:

  • Common cardiovascular risk factors include smoking, hypertension (AH), hypercholesterolemia, hypertriglyceridemia, type 2 diabetes mellitus (DM), and obesity.
  • Asymmetric dimethylarginine (ADMA) concentration is increasingly recognized for its role in cardiovascular disease pathogenesis.

Purpose of the Study:

  • To investigate the association between the quantity of cardiovascular risk factors (CVRF) and blood ADMA levels.
  • To determine if ADMA concentration serves as a biomarker for cumulative cardiovascular risk.

Main Methods:

  • A study involving 138 participants (mean age 54.90 ±10.38 years) categorized by the number of CVRF (0, 1-2, 3-4, 5-6).
  • Plasma concentrations of arginine and endogenous methylarginines, including ADMA, were measured in all participants.

Main Results:

  • Plasma ADMA concentrations were significantly elevated in participants with 1-2, 3-4, and 5-6 CVRF compared to those with none.
  • Regression analysis identified type 2 DM, AH, and hypercholesterolemia as key contributors to elevated ADMA.

Conclusions:

  • Increased blood ADMA concentration may serve as a marker for heightened cardiovascular risk.
  • The association is particularly notable in individuals with hypertension, type 2 DM, and hypercholesterolemia.
Abstract

Keywords:
arterial hypertensionasymmetric dimethylargininecardiovascular risk factorsendogenous methylargininestype 2 diabetes mellitus

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