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Updated: Aug 14, 2026

Controlled Cortical Impact Model for Traumatic Brain Injury
Published on: August 5, 2014
Critical Update on the Third Edition of the Guidelines for Managing Severe Traumatic Brain Injury in Children
Karin Reuter-Rice1, Elise Christoferson2
1Karin Reuter-Rice is an associate professor, Duke University School of Nursing, Duke University School of Medicine Department of Pediatrics, and Duke Institute for Brain Sciences, Durham, North Carolina.
Insights
Revised guidelines offer updated management strategies for severe traumatic brain injury (TBI) in children. These evidence-based recommendations aim to improve outcomes for pediatric TBI patients, guiding critical care providers.
Area of Science:
- Pediatric critical care medicine
- Neurotrauma management
Background:
- Severe traumatic brain injury (TBI) in children leads to significant mortality and disability.
- Existing evidence gaps in pediatric TBI management have been addressed by revised guidelines.
Purpose of the Study:
- To highlight key updates in the third edition of guidelines for managing severe pediatric TBI.
- To assist critical care providers in applying current, evidence-based therapies for pediatric TBI.
Main Methods:
- Overview of the evidence identification process for the guideline updates.
- Outline of current and new recommendations for pediatric severe TBI management.
Main Results:
- Specific recommendations cover neuroimaging, hyperosmolar therapy, analgesics, sedatives, seizure prophylaxis, ventilation, temperature control, nutrition, and corticosteroids.
- The full guideline document and treatment algorithms are accessible electronically.
Conclusions:
- The evidence base for pediatric TBI treatment is expanding, supporting high-quality care.
- This article serves as a quick reference for critical care providers managing severe pediatric TBI, with links to comprehensive resources.
Background:
Severe traumatic brain injury (TBI) is associated with high rates of death and disability. As a result, the revised guidelines for the management of pediatric severe TBI address some of the previous gaps in pediatric TBI evidence and management strategies targeted to promote overall health outcomes.
Objectives:
To provide highlights of the most important updates featured in the third edition of the guidelines for the management of pediatric severe TBI. These highlights can help critical care providers apply the most current and appropriate therapies for children with severe TBI.
Methods And Results:
After a brief overview of the process behind identifying the evidence to support the third edition guidelines, both relevant and new recommendations from the guidelines are outlined to provide critical care providers with the most current management approaches needed for children with severe TBI. Recommendations for neuroimaging, hyperosmolar therapy, analgesics and sedatives, seizure prophylaxis, ventilation therapies, temperature control/hypothermia, nutrition, and corticosteroids are provided. In addition, the complete guideline document and its accompanying algorithm for recommended therapies are available electronically and are referenced within this article.
Conclusions:
The evidence base for treating pediatric TBI is increasing and provides the basis for high-quality care. This article provides critical care providers with a quick reference to the current evidence when caring for a child with a severe TBI. In addition, it provides direct access links to the comprehensive guideline document and algorithms developed to support critical care providers.

