Related Experiment Video
Updated: Dec 30, 2025

Application of Genetically Encoded Fluorescent Nitric Oxide (NO•) Probes, the geNOps, for Real-time Imaging of NO• Signals in Single Cells
Published on: March 16, 2017
Nitric oxide as a developmental and metabolic signal in filamentous fungi
Yanxia Zhao1, Jieyin Lim2, Jianyang Xu3
1Key Laboratory for Biotechnology of Medicinal Plants, Jiangsu Normal University, Xuzhou, China.
Abstract:
The short-lived hydrophobic gas nitric oxide (NO) is a broadly conserved signaling molecule in all domains of life, including the ubiquitous and versatile filamentous fungi (molds). Several studies have suggested that NO plays a vast and diverse signaling role in molds. In this review, we summarize NO-mediated signaling and the biosynthesis and degradation of NO in molds, and highlight the recent advances in understanding the NO-mediated regulation of morphological and physiological processes throughout the fungal life cycle. In particular, we describe the role of NO in molds as a signaling molecule that modulates asexual and sexual development, the formation of infection body appressorium, and the production of secondary metabolites (SMs). In addition, we also summarize NO detoxification and protective mechanisms against nitrooxidative stress.
Related Concept Videos
Nitric Oxide Signaling Pathway
Yeast Signaling
Paracrine Signaling
Inorganic Nitrogen Assimilation
Regulation of Angiogenesis and Blood Supply
Types of Signaling Molecules

