Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

The erythrocyte sedimentation rates: some model experiments.

L C Cerny1, E L Cerny, C R Granley

  • 1Utica College, Syracuse University, N.Y.

Biorheology
|January 1, 1988
PubMed
Summary

This study models erythrocyte sedimentation rate (ESR) using Cheerios and space experiments to understand red blood cell aggregation and fractal behavior. Roughened tubes enhanced sedimentation, revealing gravity

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Mental health promotion in high risk groups.

Quality in health care : QHC·1997
Same author

The effect of biological media on the hydrolysis of mustard simulants.

Biomedical sciences instrumentation·1997
Same author

A starch-hemoglobin resuscitative compound.

Artificial cells, blood substitutes, and immobilization biotechnology·1996
Same author

Mixtures of erythrocytes and acellular fluids: an in vitro evaluation.

Artificial cells, blood substitutes, and immobilization biotechnology·1994
Same author

Interleukin-1 as a possible agent for treatment of infection.

European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology·1993
Same author

Stabilized hemoglobins as acellular resuscitative fluids.

Biomaterials, artificial cells, and immobilization biotechnology : official journal of the International Society for Artificial Cells and Immobilization Biotechnology·1992

Area of Science:

  • Biophysics
  • Fluid Dynamics
  • Biomedical Engineering

Background:

  • Erythrocyte sedimentation rate (ESR) is a key diagnostic marker.
  • Understanding red blood cell aggregation and packing is crucial for interpreting ESR.
  • Previous models often simplify the complex structure of red blood cell mixtures.

Purpose of the Study:

  • To model erythrocyte sedimentation rate (ESR) using macroscopic and biological systems.
  • To investigate the effect of red blood cell structure and rouleaux formation on sedimentation.
  • To explore self-similarity and fractal behavior in erythrocyte aggregation under varying gravity conditions.

Main Methods:

  • Utilized "Cheerios" as a macroscopic model for red blood cell packing and rouleaux formation.
  • Employed Dintenfass's split-capillary photo viscometer experiments with whole blood under 1g and near-zero gravity (Space Shuttle "Discovery").

Related Experiment Videos

  • Analyzed sedimentation rates in smooth versus roughened interior sedimentation tubes.

    • Main Results:

    • "Cheerios" exhibited similar volume distribution to erythrocytes.
    • Rouleaux size and aggregate formation were dependent on gravity.
    • Fractal dimensions calculated from the "Cheerios" model and "Discovery" experiment showed agreement with sedimentimeter data.
    • Roughened sedimentation tubes led to more rapid erythrocyte settling compared to smooth tubes.

    Conclusions:

    • Geometrical and macroscopic models like "Cheerios" can effectively represent red blood cell packing and aggregation.
    • Gravity significantly influences erythrocyte aggregate size and rouleaux formation.
    • The study provides insights into fractal behavior in sedimentation processes.
    • Surface texture of sedimentation tubes impacts settling rates, suggesting potential for improved diagnostic methods.