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Detection and Isolation of Apoptotic Bodies to High Purity
Published on: August 12, 2018
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Apoptotic Bodies: Particular Extracellular Vesicles Involved in Intercellular Communication
Michela Battistelli1, Elisabetta Falcieri1
1Department of Biomolecular Sciences (DiSB), Urbino University Carlo Bo, 61029 Urbino (PU), Italy.
Biology
|January 24, 2020
Summary
Extracellular vesicles (EVs), including exosomes and microvesicles, are key to cell-cell communication and information transfer. Further research is needed to understand the function of less-known apoptotic bodies (ApoBDs).
Area of Science:
- Cell Biology
- Biochemistry
- Molecular Biology
Background:
- Cell-cell communication is crucial for biological processes.
- Membranous extracellular vesicles (EVs) have emerged as significant mediators of this communication.
- EVs encompass exosomes, microvesicles, and apoptotic bodies (ApoBDs), each with distinct characteristics and roles.
Purpose of the Study:
- To review the morpho-functional characteristics of extracellular vesicles.
- To highlight the role of EVs in intercellular communication and cellular content removal.
- To emphasize the need for further investigation into apoptotic bodies.
Main Methods:
- Literature review of current research on extracellular vesicles.
- Analysis of morphological and functional properties of exosomes, microvesicles, and ApoBDs.
- Synthesis of data on EV biogenesis, content, and release mechanisms.
Main Results:
- EVs vary in size, origin, and cargo, influencing their specific functions.
- Exosomes and microvesicles are established carriers of genetic information between cells.
- Apoptotic bodies (ApoBDs) are less understood but represent a significant area for future research.
Conclusions:
- Extracellular vesicles are vital for intercellular signaling and homeostasis.
- Understanding the diverse functions of EVs, particularly ApoBDs, is critical for advancing biological and medical sciences.
- This review provides a foundation for future studies on EV biology and therapeutic potential.
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