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An implantable semiconductor beta-radiation detector.

E M Khouri, R A Olsson, J L Bedynek

    The American Journal of Physiology
    |January 1, 1977
    PubMed
    Summary
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    This study introduces an implantable beta-radiation detector for measuring regional blood flow in animals. The device shows good agreement with mechanical systems but has limitations in high-flow conditions and myocardial blood flow comparisons.

    Area of Science:

    • Biomedical Engineering
    • Medical Physics
    • Physiology

    Background:

    • Accurate measurement of regional blood flow is crucial for understanding physiological processes and disease.
    • Existing methods for blood flow measurement have limitations in accuracy, invasiveness, or applicability to specific tissues.

    Purpose of the Study:

    • To describe an implantable beta-radiation detector for regional blood flow measurement in experimental animals.
    • To evaluate the accuracy and reliability of this novel detector.
    • To compare its performance with established blood flow assessment techniques.

    Main Methods:

    • Development and implantation of a lithium-drifted silicon diode detector.
    • Use of a beta-emitting isotope (e.g., 85Kr) for indicator clearance principle.

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  • Calibration against a mechanical system and in vivo comparisons with precordial counter and microsphere techniques.

    • Main Results:

    • The detector demonstrated excellent agreement with mechanical calibration up to 600 ml/100 g per min.
    • At very high flow rates, flow was underestimated by a maximum of 10%.
    • In vivo comparisons of myocardial blood flow showed poor agreement with precordial counter and microsphere methods.

    Conclusions:

    • The implantable beta-radiation detector is a viable tool for regional blood flow measurement in experimental animals.
    • Discrepancies in myocardial blood flow measurements may be due to tissue heterogeneity or methodological limitations.
    • The device maintained functionality for over 50 days in chronic animal studies.