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Updated: Dec 30, 2025

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A Water-Soluble Copper(II) Complex for the Selective Fluorescence Detection of Nitric Oxide/Nitroxyl and Imaging in
Xiaolong Sun1, Gyoungmi Kim2, Yufang Xu3
1Department of Chemistry, University of Bath, Bath, BA2 7AY, United Kingdom.
Abstract:
A novel water-soluble copper(II) naphthalimide complex fluorescent probe was devised and displayed significant fluorescence turn-on response for nitric oxide and nitroxyl over other biologically relevant reactive oxygen species under physiological conditions. The dual-analyte recognition of this simple and sensitive probe was successfully applied for the imaging of exogenous and endogenous NO and HNO in living cells.
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