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Related Experiment Video

Updated: Dec 30, 2025

Synthesis of Core-shell Lanthanide-doped Upconversion Nanocrystals for Cellular Applications
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Ultrabright Lanthanide Nanoparticles.

Joan Goetz1, Aline Nonat1, Abdoulaye Diallo1

  • 1Laboratoire d'Ingénierie Moléculaire Appliquée à l'Analyse, Institut Pluridisciplinaire Hubert Curien, École Européenne de Chimie, Polymères et Matériaux, IPHC, UMR 7178, CNRS/Université de Strasbourg, 25 rue Becquerel, 67087, Strasbourg Cedex, France.

Chempluschem
|January 24, 2020
PubMed
Summary
This summary is machine-generated.

Surface functionalization of terbium-doped lanthanum fluoride nanoparticles with antenna ligands creates ultrabright nanoparticles for cellular imaging. These lanthanide dots offer long excited-state lifetimes and high brightness for luminescence microscopy.

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Area of Science:

  • Nanotechnology
  • Materials Science
  • Biomedical Imaging

Background:

  • Lanthanide-doped nanoparticles offer unique optical properties for bioimaging applications.
  • Surface modification is crucial for enhancing nanoparticle performance and biocompatibility.
  • Photon-harvesting antenna ligands can improve the excitation efficiency of lanthanide ions.

Purpose of the Study:

  • To develop ultrabright terbium-doped lanthanum fluoride (LaF3) nanoparticles.
  • To investigate the effect of surface functionalization with photon-harvesting antenna ligands on nanoparticle properties.
  • To evaluate the suitability of these nanoparticles for luminescence microscopy in living cells.

Main Methods:

  • Synthesis of terbium-doped LaF3 nanoparticles.
  • Surface functionalization with antenna ligands.
  • Characterization of optical properties, including luminescence and excited-state lifetimes.
  • Cellular incorporation and imaging using luminescence microscopy.

Main Results:

  • Surface capping with antenna ligands resulted in ultrabright nanoparticles.
  • The nanoparticles exhibited the characteristic green luminescence of terbium (Tb) atoms.
  • Long excited-state lifetimes were observed for the functionalized nanoparticles.
  • Successful incorporation into living cells at nanomolar concentrations for imaging was demonstrated.

Conclusions:

  • Surface functionalization with antenna ligands significantly enhances the brightness and optical properties of Tb-doped LaF3 nanoparticles.
  • These engineered lanthanide dots are highly suitable for sensitive luminescence microscopy imaging in biological systems.
  • The developed nanoparticles represent a promising tool for advanced cellular imaging techniques.