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Related Experiment Video

Updated: Dec 30, 2025

Synthesis of Core-shell Lanthanide-doped Upconversion Nanocrystals for Cellular Applications
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Ultrabright Lanthanide Nanoparticles.

Joan Goetz1, Aline Nonat1, Abdoulaye Diallo1

  • 1Laboratoire d'Ingénierie Moléculaire Appliquée à l'Analyse, Institut Pluridisciplinaire Hubert Curien, École Européenne de Chimie, Polymères et Matériaux, IPHC, UMR 7178, CNRS/Université de Strasbourg, 25 rue Becquerel, 67087, Strasbourg Cedex, France.

Chempluschem
|January 24, 2020
PubMed
Summary
This summary is machine-generated.

Terbium-doped lanthanum fluoride (Tb-doped LaF3) nanoparticles were synthesized and functionalized with photosensitizing ligands. These bright nanoparticles were successfully used for imaging lysosomes in HeLa cells.

Keywords:
antenna effectslanthanidesluminescencemicroscopynanoparticles

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Area of Science:

  • Nanomaterials Science
  • Biophotonics
  • Inorganic Chemistry

Background:

  • Lanthanum fluoride nanoparticles offer unique optical properties.
  • Functionalization of nanoparticles is crucial for targeted applications.
  • Terbium doping enhances luminescence for bioimaging.

Purpose of the Study:

  • To develop a microwave-assisted synthesis for Tb-doped LaF3 nanoparticles.
  • To design and evaluate photosensitizing ligands for nanoparticle functionalization.
  • To assess the brightness and cellular imaging capabilities of the functionalized nanoparticles.

Main Methods:

  • Microwave-assisted synthesis in aqueous media.
  • Characterization using XRD, TEM, DLS, and ICP-AES.
  • Ligand design and spectroscopic analysis (absorption, emission).
  • Cellular imaging in HeLa cells via fluorescence microscopy.

Main Results:

  • Successful synthesis of Tb-doped LaF3 nanoparticles.
  • Identification of highly effective photosensitizing ligands.
  • Achieved high molar absorptivities (up to 1.6×10^7 m⁻¹cm⁻¹) and brightness.
  • Demonstrated specific localization in lysosomes of HeLa cells.

Conclusions:

  • Microwave synthesis provides a reproducible route to Tb-doped LaF3 nanoparticles.
  • Functionalization with specific ligands significantly enhances nanoparticle brightness.
  • The developed nanoparticles are suitable for lysosomal imaging in live cells.