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DLEU1: A Functional Long Noncoding RNA in Tumorigenesis

Chaoying Song1,2, Jiali Zhang1,2, Zongyao Zhao1,2

  • 1China Three Gorges University, School of Medicine, Yichang, 443002, Hubei, China.

Current Pharmaceutical Design
|January 24, 2020
PubMed
Abstract

Insights

Long non-coding RNA DLEU1 (lncRNA DLEU1) is elevated in many cancers and drives tumor growth. This lncRNA shows promise as a diagnostic biomarker and therapeutic target for various malignancies.

Area of Science:

  • Molecular Biology
  • Oncology
  • Genetics

Background:

  • Long non-coding RNAs (lncRNAs) play critical roles in biological processes.
  • lncRNA DLEU1 is implicated in the pathophysiology of human diseases, particularly in cancer development.
  • DLEU1 may serve as a potential target for cancer biotherapy.

Purpose of the Study:

  • To review and analyze the pathophysiological functions and mechanisms of lncRNA DLEU1 in various cancer types.
  • To consolidate current research on DLEU1's role in tumor development.

Main Methods:

  • Systematic literature retrieval from PubMed.
  • Summary and analysis of existing studies on DLEU1's biological functions and mechanisms in tumors.

Main Results:

  • DLEU1 is frequently overexpressed in numerous cancers, including osteosarcoma, glioma, and hepatocellular carcinoma.
  • lncRNA DLEU1 is involved in promoting cancer cell proliferation, migration, and invasion.
  • DLEU1 also plays a role in inhibiting apoptosis in cancer cells.

Conclusions:

  • lncRNA DLEU1 is a significant cancer-associated lncRNA.
  • DLEU1 is a potential biomarker for early cancer detection.
  • DLEU1 represents a promising therapeutic target for multiple tumor types.
Keywords:
DLEU1Long non-coding RNAbiomarkermultiple tumorspotential therapeutic targettumorigenesis.

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