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Related Concept Videos

lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

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In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
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lncRNA - Long Non-coding RNAs02:39

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Non-LTR Retrotransposons03:18

Non-LTR Retrotransposons

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As the name suggests, non-LTR retrotransposons lack the long terminal repeats characteristic of the LTR retrotransposons. Additionally, both LTR and non-LTR retrotransposons use distinct mechanisms of mobilization. Non-LTR retrotransposons are further divided into two classes - Long interspersed nuclear elements (LINEs) and short interspersed nuclear elements (SINEs), both of which occur abundantly in most mammals, including humans. Some of the active non-LTR retrotransposons in humans are L1...
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MicroRNAs01:22

MicroRNAs

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MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...
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MicroRNAs01:22

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MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After...
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Types of RNA01:20

Types of RNA

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Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in regulating gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
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DLEU1: A Functional Long Noncoding RNA in Tumorigenesis.

Chaoying Song1,2, Jiali Zhang1,2, Zongyao Zhao1,2

  • 1China Three Gorges University, School of Medicine, Yichang, 443002, Hubei, China.

Current Pharmaceutical Design
|January 24, 2020
PubMed
Summary

Long non-coding RNA DLEU1 (lncRNA DLEU1) is elevated in many cancers and drives tumor growth. This lncRNA shows promise as a diagnostic biomarker and therapeutic target for various malignancies.

Keywords:
DLEU1Long non-coding RNAbiomarkermultiple tumorspotential therapeutic targettumorigenesis.

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Area of Science:

  • Molecular Biology
  • Oncology
  • Genetics

Background:

  • Long non-coding RNAs (lncRNAs) play critical roles in biological processes.
  • lncRNA DLEU1 is implicated in the pathophysiology of human diseases, particularly in cancer development.
  • DLEU1 may serve as a potential target for cancer biotherapy.

Purpose of the Study:

  • To review and analyze the pathophysiological functions and mechanisms of lncRNA DLEU1 in various cancer types.
  • To consolidate current research on DLEU1's role in tumor development.

Main Methods:

  • Systematic literature retrieval from PubMed.
  • Summary and analysis of existing studies on DLEU1's biological functions and mechanisms in tumors.

Main Results:

  • DLEU1 is frequently overexpressed in numerous cancers, including osteosarcoma, glioma, and hepatocellular carcinoma.
  • lncRNA DLEU1 is involved in promoting cancer cell proliferation, migration, and invasion.
  • DLEU1 also plays a role in inhibiting apoptosis in cancer cells.

Conclusions:

  • lncRNA DLEU1 is a significant cancer-associated lncRNA.
  • DLEU1 is a potential biomarker for early cancer detection.
  • DLEU1 represents a promising therapeutic target for multiple tumor types.