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Identifying Coronary Artery Calcification on Non-gated Computed Tomography Scans
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The Association Between Coronary Artery Calcification and Subclinical Cerebrovascular Diseases in Men: An

Md Maruf Haque Khan1,2,3, Akira Fujiyoshi1,4, Akihiko Shiino5

  • 1Department of Public Health, Shiga University of Medical Science.

Journal of Atherosclerosis and Thrombosis
|January 24, 2020
PubMed

Insights

Coronary artery calcification (CAC) is linked to increased odds of stroke and dementia. Higher CAC scores in Japanese men correlated with lacunar infarction, white matter hyperintensity, and intracranial arterial stenosis.

Area of Science:

  • Cardiovascular Imaging and Neurology
  • Cerebrovascular Disease Research
  • Public Health and Epidemiology

Background:

  • Coronary artery calcification (CAC) is a recognized predictor of stroke and dementia.
  • Subclinical cerebrovascular diseases (SCVDs) are implicated in the pathogenesis of stroke and dementia.
  • The association between CAC and SCVDs requires further investigation, particularly in diverse populations.

Purpose of the Study:

  • To investigate the relationship between coronary artery calcification (CAC) and subclinical cerebrovascular diseases (SCVDs).
  • To assess the prevalence of SCVDs in relation to varying degrees of CAC in a healthy Japanese male cohort.

Main Methods:

  • An observational study involving 709 stroke-free Japanese men (2010-2014).
  • Coronary artery calcification (CAC) was quantified using the Agatston method.
  • Magnetic resonance imaging (MRI) assessed intracranial arterial stenosis (ICAS), lacunar infarction, deep and subcortical white matter hyperintensity (DSWMH), periventricular hyperintensity (PVH), and microbleeds.

Main Results:

  • Participants with moderate-to-severe CAC (＞100) exhibited significantly higher odds of lacunar infarction, DSWMH, and ICAS.
  • No significant associations were found between CAC and microbleeds or PVH.
  • A significant trend (P ≤ 0.02) was observed between increasing CAC scores and the prevalence of lacunar infarction, DSWMH, and ICAS.

Conclusions:

  • Elevated coronary artery calcification (CAC) scores are associated with increased odds of specific subclinical cerebrovascular diseases (SCVDs), including lacunar infarction, DSWMH, and ICAS.
  • CAC may serve as a valuable clinical indicator for identifying individuals at risk for SCVDs affecting both small and large cerebral vessels.
Abstract

Keywords:
AtherosclerosisCoronary artery calcificationSubclinical cerebrovascular diseases

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