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Baseline High Blood Pressure is Associated with Clinico-Pathologic Findings and Later Renal Progression in Chronic

Ji Yung Lee1, Hyung-Seok Ihm1, Jin Sug Kim1

  • 1Department of Nephrology, Kyung-Hee University Hospital, Kyung-Hee University School of Medicine, Seoul, Korea.

Electrolyte & Blood Pressure : E & BP
|January 24, 2020
PubMed

Insights

High baseline blood pressure in IgA nephropathy is linked to worse kidney function and progression. Elevated systolic blood pressure correlates with increased proteinuria and markers of kidney damage, impacting long-term renal outcomes.

Area of Science:

  • Nephrology
  • Hypertension Research
  • Glomerular Disease Studies

Background:

  • Hypertension is a known complication of chronic glomerulonephritis (GN).
  • Factors contributing to hypertension in GN require further investigation.
  • Understanding baseline blood pressure's role is crucial for predicting renal outcomes.

Purpose of the Study:

  • To investigate the association between baseline blood pressure (BP) and pathophysiologic findings in chronic GN.
  • To determine the relationship between baseline BP and later renal progression in patients with IgA nephropathy.

Main Methods:

  • Analysis of clinico-pathological data from 233 IgA nephropathy patients.
  • Measurement of serum creatinine, proteinuria, urinary sodium excretion, glomerular surface area (GSA), and urine angiotensinogen (AGT).
  • Correlation analysis between baseline systolic BP and various clinical and pathological parameters, including follow-up estimated glomerular filtration rate (eGFR).

Main Results:

  • 53% of patients had systolic BP ≥130 mmHg.
  • Higher baseline systolic BP correlated with older age, increased serum creatinine, proteinuria, urinary sodium excretion, GSA, and tubulointerstitial fibrosis.
  • Elevated systolic BP was associated with lower follow-up eGFR and a steeper decline in eGFR over time.

Conclusions:

  • Baseline systolic blood pressure is significantly associated with urinary sodium excretion, glomerulomegaly, and tubulointerstitial fibrosis in IgA nephropathy.
  • Elevated baseline systolic BP is a predictor of later renal progression in patients with IgA nephropathy.
Abstract

Keywords:
AngiotensinogenBlood pressureGlomerulomegalyNa excretionPathologyProgressioneGFR

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