Related Experiment Video
Updated: Dec 30, 2025
06:32
Evaluation of Biomarkers in Glioma by Immunohistochemistry on Paraffin-Embedded 3D Glioma Neurosphere Cultures
Published on: January 9, 2019
8.2K
Recent Advances in Meningioma Immunogenetics
May Al-Rashed1, Kara Foshay2,3, Malak Abedalthagafi4
1Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, King Saud University, Riyadh, Saudi Arabia.
Frontiers in Oncology
|January 24, 2020
Summary
Meningiomas are common brain tumors. Advances in molecular profiling and immunophenotyping offer new diagnostic and prognostic markers for better meningioma treatment and personalized therapies.
Area of Science:
- Neuro-oncology
- Tumor biology
- Genomics
Background:
- Meningiomas are common intracranial tumors, often benign and curable by surgery.
- High-grade meningiomas are aggressive, recurring frequently and leading to poor outcomes.
- Current diagnostic and prognostic methods for meningioma subtypes are insufficient.
Purpose of the Study:
- To review advances in molecular profiling and immunophenotyping of meningiomas.
- To highlight the need for improved diagnostic and prognostic markers.
- To discuss the potential for personalized therapeutic strategies.
Main Methods:
- Review of current literature on meningioma molecular profiling.
- Analysis of immunophenotyping techniques for meningioma classification.
- Synthesis of data on diagnostic and prognostic marker development.
Main Results:
- Molecular profiling and immunophenotyping reveal meningioma heterogeneity.
- These techniques offer potential for more accurate diagnosis and prognosis.
- Advances may lead to the identification of novel therapeutic targets.
Conclusions:
- Improved molecular and immunophenotypic markers are crucial for meningioma management.
- Personalized therapeutic strategies can be developed based on these advances.
- Further research is needed to translate these findings into clinical practice.
