Correlation between Metabolic Syndrome and Intracranial versus Extracranial Arteriosclerosis among Chinese Patients with Stroke
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Updated: Dec 30, 2025
Evaluation of the Cognitive Performance of Hypertensive Patients with Silent Cerebrovascular Lesions
Published on: April 23, 2021
Chunyu Liu1, Xiaodan Yang1, Changqing Chen1
1Department of Neurology, PLA 254 Hospital, Tianjin 300141, P.R. China.
Insights
Metabolic syndrome significantly correlates with intracranial arteriosclerosis, increasing its risk. This link was not found for extracranial arteriosclerosis, suggesting a specific association with brain arteries.
Area of Science:
- Neurology
- Cardiology
- Endocrinology
Background:
- Investigated the link between metabolic syndrome and arteriosclerosis in older adults.
- Focused on intracranial and extracranial arterial disease in patients with cerebral infarction or TIA.
- Utilized digital subtraction angiography (DSA) for arterial assessment.
Purpose of the Study:
- To determine the correlation between metabolic syndrome and intracranial versus extracranial arteriosclerosis.
- To identify specific metabolic syndrome components associated with these vascular conditions.
Main Methods:
- Compared 192 patients with intracranial and extracranial arteriosclerosis to a control group of 196 patients.
- Assessed the prevalence and components of metabolic syndrome in study participants.
- Analyzed correlations between metabolic syndrome and arteriosclerosis using statistical methods.
Main Results:
- Metabolic syndrome prevalence was 31.4% in the study population.
- Intracranial arteriosclerosis group showed higher metabolic syndrome component prevalence and values.
- Significant correlation found between metabolic syndrome and intracranial arteriosclerosis (P<0.001), but not extracranial arteriosclerosis (P<0.001).
- Hyperglycemia and hypertension were significantly correlated with intracranial arteriosclerosis.
- Hyperglycemia was also correlated with extracranial arteriosclerosis.
Conclusions:
- Metabolic syndrome appears to increase the risk of developing intracranial arteriosclerosis.
- At least three metabolic syndrome components significantly elevate the risk for intracranial arteriosclerosis.
- The association between metabolic syndrome and arteriosclerosis may be specific to intracranial vessels.
Background:
We aimed to explore the correlation between metabolic syndrome and intracranial and extra-cranial arteriosclerosis. Overall, 318 over 60-yr-old patients with cerebral infarction or TIA who were examined by digital subtraction angiography (DSA) in our hospital were enrolled in the study.
Methods:
Overall, 192 patients with intracranial and extracranial arteriosclerosis were admitted to the case group (the intracranial and extracranial arteriosclerosis group). Also, 196 patients, suffering from the same condition, were selected from our outpatient clinic and enrolled in the control group.
Results:
The prevalence of metabolic syndrome was 31.4%. The prevalence of each metabolic syndrome component in the intracranial arteriosclerosis group was higher than those of the extracranial arteriosclerosis and the control groups. The average component values in the intracranial arteriosclerosis group was higher than those observed in other groups. The prevalence rate of metabolic syndrome had no significant difference among different degrees of stenosis for extracranial arteriosclerosis group. There was a remarkable correlation between intracranial arteriosclerosis and metabolic syndrome (P<0.001), while no correlation was detected between extracranial arteriosclerosis and metabolic syndrome (P<0.001). We concluded that metabolic syndrome may increase the prevalence risk of intracranial arteriosclerosis. There was a significant correlation between intracranial arteriosclerosis and metabolic syndrome components including hyperglycemia and hypertension. Also, there was a significant correlation between extracranial arteriosclerosis and metabolic syndrome components including hyperglycemia.
Conclusion:
We believe that at least three components of metabolic syndrome can obviously increase the risk of intracranial arteriosclerosis.
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