Related Experiment Video

Updated: Dec 30, 2025

Author Spotlight: Exploring the Role of Inflammation in the Co-occurrence of Primary Sjogren's Syndrome and Lung Adenocarcinoma
10:21

Author Spotlight: Exploring the Role of Inflammation in the Co-occurrence of Primary Sjogren's Syndrome and Lung Adenocarcinoma

Published on: September 20, 2024

688

The Effect of lnterleukin-6 Gene Polymorphism on Pediatric Pneumonia

Guode Su1, Lili Ding2, Zhenkun Zhang1

  • 1Department II of Pediatric Respiration, Xuzhou Children Hospital, Xuzhou Medical University, Xuzhou, P.R. China.

Iranian Journal of Public Health
|January 24, 2020
PubMed

Insights

Interleukin-6 (IL-6) gene polymorphism is linked to pediatric pneumonia. Individuals with the G allele at this locus show a higher susceptibility to developing this respiratory illness.

Area of Science:

  • Genetics
  • Pediatrics
  • Immunology

Background:

  • Pediatric pneumonia poses a significant health challenge.
  • Interleukin-6 (IL-6) is a cytokine involved in inflammatory responses.
  • Genetic variations, specifically gene polymorphism, may influence disease susceptibility.

Purpose of the Study:

  • To investigate the association between interleukin-6 (IL-6) gene polymorphism and the risk of pediatric pneumonia.
  • To determine if specific IL-6 genotypes or alleles correlate with increased susceptibility to pediatric pneumonia.

Main Methods:

  • A case-control study involving 438 pediatric pneumonia patients and 423 healthy children.
  • Polymerase Chain Reaction (PCR) was used to amplify and detect the IL-6-572 gene fragment.
  • Genotyping analysis was performed to compare allele and genotype frequencies between patient and control groups.

Main Results:

  • Significant differences in IL-6 genotypes were observed between pediatric pneumonia patients and healthy controls (P<0.05).
  • The G allele frequency was notably higher in the observation group compared to the control group (P<0.05).
  • Carriers of the GC genotype had a 2.13-fold increased risk, and GG genotype carriers had a 5.56-fold increased risk of pediatric pneumonia compared to the CC genotype.

Conclusions:

  • IL-6 gene polymorphism, specifically at the -572 locus, is associated with pediatric pneumonia.
  • The presence of the G allele in the IL-6 gene may confer a higher predisposition to developing pediatric pneumonia.
Abstract

Keywords:
Community acquired pneumoniaGene polymorphismInterleukin-6Pediatric pneumonia

More Related Videos

Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry05:53

Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry

Published on: June 21, 2018

10.5K
An IL-8 Transiently Transgenized Mouse Model for the In Vivo Long-term Monitoring of Inflammatory Responses08:16

An IL-8 Transiently Transgenized Mouse Model for the In Vivo Long-term Monitoring of Inflammatory Responses

Published on: July 7, 2017

7.9K

Related Concept Videos

Pneumonia II: Pathophysiology01:29

Pneumonia II: Pathophysiology

The pathophysiology of pneumonia involves the following steps:
2.4K
Single Nucleotide Polymorphisms-SNPs01:05

Single Nucleotide Polymorphisms-SNPs

A single nucleotide polymorphism or SNP is a single nucleotide variation at a specific genomic position in a large population. It is the most prevalent type of sequence variation found in the human genome. Point mutations that occur in more than 1% of the population qualify as SNPs. These are present once every 1000 nucleotides on an average in the human genome. Replacement of a purine with another purine (A/G) or a pyrimidine with another pyrimidine (C/T) is known as a transition. In contrast,...
17.8K
Chronic Obstructive Pulmonary Disease-II: Pathophysiology01:20

Chronic Obstructive Pulmonary Disease-II: Pathophysiology

Chronic Obstructive Pulmonary Disease (COPD) pathophysiology is intricate and multifaceted, involving a complex interplay of physiological processes. Understanding these mechanisms is crucial for effectively managing and treating COPD. Here is an in-depth look at the critical elements in the pathophysiology of COPD:
Chronic Inflammation
4.1K
Pneumonia I: Introduction01:30

Pneumonia I: Introduction

Pneumonia is an acute respiratory infection that targets the lungs, specifically the alveoli. These tiny air sacs, essential for oxygen exchange, become engorged with pus and fluid, severely hindering breathing, decreasing oxygen absorption, and causing significant pain and discomfort during respiration.
Risk Factors
Various factors influence the likelihood of developing pneumonia. Age plays a crucial role, with infants, children under two, and individuals over 65 at increased risk due to their...
659