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Mesenchymal stem cell-based tissue regeneration therapies for periodontitis
Takehito Ouchi1, Taneaki Nakagawa1
1Department of Dentistry and Oral Surgery, Keio University School of Medicine, Shinjuku-ku, Tokyo, 160-8582, Japan.
Regenerative Therapy
|January 24, 2020
Summary
Periodontitis, a common dental concern, lacks effective tissue regeneration. Mesenchymal stem cell transplantation shows promise for regenerating periodontal tissues, advancing regenerative medicine.
Area of Science:
- Dental Medicine
- Developmental Biology
- Regenerative Medicine
Background:
- Periodontitis is a prevalent oral disease with complex causes, including microbial imbalance and systemic conditions like diabetes.
- Current treatments focus on pathogen removal and bone defect repair, but do not fully regenerate periodontal tissues.
- Understanding periodontal tissue development, originating from neural crest-derived ectomesenchyme, is key to achieving regeneration.
Purpose of the Study:
- To review the fundamental knowledge of periodontal tissue regeneration.
- To explore the potential of mesenchymal stem cells in periodontal regenerative medicine.
Main Methods:
- Review of recent studies on mesenchymal stem cell transplantation for periodontal regeneration.
- Discussion of developmental biology principles related to periodontal tissues.
Main Results:
- Mesenchymal stem cell transplantation has demonstrated efficacy in periodontal tissue regeneration.
- Recent research highlights the potential of stem cell-based approaches.
Conclusions:
- Mesenchymal stem cells offer a promising avenue for periodontal regenerative medicine.
- Further understanding of developmental processes and cell interactions is crucial for advancing periodontal regeneration.
Keywords:
BMMSCs, bone marrow MSCsBMP, bone morphogenetic proteinC-MSCs, clumps of MSC/ECM complexesDFSCs, dental follicle stem cellsECM, extracellular matrixFGF, fibroblast growth factorGDF-5, growth/differentiation factor-5HERS, Hertwig epithelial root sheathIFN-γ, interferon-gammaIGFBP-6, insulin-like growth factor binding protein-6LepR, leptin receptorMSCs, mesenchymal stem cellsMesenchymal stem cellsNCCs, neural crest cellsPDGFRα, platelet derived growth factor receptor αPDL, periodontal ligamentPDLSCs, periodontal ligament stem cellsPeriodontal tissuePeriodontitisPluripotent stem cellsTNF-α, tumor necrosis factor-alphaTissue regenerationWnt, wingless-INTiPSC-MSCs, iPSC-derived MSCsiPSCs, induced pluripotent stem cellsscRNA-seq, single-cell RNA sequence
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