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Related Concept Videos

Skeletal Muscle Relaxants: Therapeutic Uses01:31

Skeletal Muscle Relaxants: Therapeutic Uses

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Skeletal muscle relaxants are used to relax muscle tone and alleviate painful muscle contractions. However, the choice of skeletal muscle relaxants depends on the duration of the surgical procedure in order to minimize potential side effects. Skeletal muscle relaxants like neuromuscular blocking agents [NMBAs] are commonly employed as adjuvants alongside general anesthetics in clinical settings. NMBAs are also used to maintain controlled ventilation during surgery of the larynx or pharynx...
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The clinical conditions affecting the skeletal muscle tissue are broadly categorized as musculoskeletal and neuromuscular disorders.
Musculoskeletal disorders
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Myasthenia gravis is a neuromuscular transmission disorder characterized by weakness and increased fatigability of skeletal muscles. It is an autoimmune disease affecting approximately one in 2000 people, where antibodies against the α1 subunit of nicotinic acetylcholine receptors are produced.
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Skeletal muscle relaxants are a group of drugs that can reduce muscle stiffness and induce temporary paralysis to relieve pain. These agents can act centrally to reduce muscle tone or spasms in painful conditions such as multiple sclerosis (MS), amyotrophic lateral sclerosis (ALS), or spinal injuries; they are called antispasmodics or spasmolytics.
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Satellite stem cells or myosatellite cells are quiescent stem cells that Alexander Mauro first identified in 1961. These cells are located between the sarcolemma, the plasma membrane of muscle fibers, and the basal lamina, the connective tissue sheath covering it. These mononucleated cells are activated in response to muscle injury, can transform into myoblasts, and may form or repair muscle fibers. Myosatellite cells can provide additional myonuclei for muscle regeneration or return to a...
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Vascular Occlusion Training for Inclusion Body Myositis: A Novel Therapeutic Approach
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Exercise therapy in muscle diseases: open issues and future perspectives.

Gabriele Siciliano1, Erika Schirinzi1, Costanza Simoncini1

  • 1Department of Clinical and Experimental Medicine, Neurological Clinic, University of Pisa, Italy.

Acta Myologica : Myopathies and Cardiomyopathies : Official Journal of the Mediterranean Society of Myology
|January 24, 2020
PubMed
Summary

Supervised aerobic exercise training is safe and effective for improving muscle function in patients with muscle diseases. Personalized exercise programs are key to maximizing benefits and preventing damage in these conditions.

Keywords:
muscle diseasesmuscle exercise therapymuscle fatigue

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Area of Science:

  • Neurology
  • Exercise Physiology
  • Rehabilitation Medicine

Background:

  • Muscle diseases involve diverse molecular mechanisms leading to impaired muscle contraction and exercise intolerance.
  • Exercise therapy offers a potential strategy to combat muscle fiber dysfunction and sedentary lifestyle effects in motor impairments.

Purpose of the Study:

  • To evaluate the safety and efficacy of supervised aerobic exercise training in patients with muscle disorders.
  • To explore the role of personalized exercise in improving muscle function and oxidative capacity.

Main Methods:

  • Review of existing reports on supervised aerobic exercise training in various muscle disorders.
  • Emphasis on personalized exercise prescription and monitoring of patient capability.
  • Discussion of advancements in outcome measurement and exercise monitoring.

Main Results:

  • Supervised aerobic exercise training is generally safe for patients with muscle disorders.
  • Exercise training can improve oxidative capacity and muscle function.
  • Personalization of exercise intensity and type is crucial for effectiveness.

Conclusions:

  • Supervised aerobic exercise training is a safe and effective component of rehabilitation for muscle diseases.
  • Personalized exercise programs, coupled with advanced monitoring, can enhance outcomes.
  • Exercise should be strictly supervised to prevent potential muscle damage and integrate with emerging therapies.