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Introducing Tween-curcumin niosomes: preparation, characterization and microenvironment study.

Anand Kumar Sahu1, Jhili Mishra1, Ashok Kumar Mishra1

  • 1Department of Chemistry, Indian Institute of Technology Madras, Chennai 600 036, India. mishra@iitm.ac.in.

Soft Matter
|January 24, 2020
PubMed
Summary
This summary is machine-generated.

Curcumin, a probiotic, unexpectedly stabilizes niosomes (non-ionic surfactant based vesicles) made with Tween surfactants. These curcumin-loaded niosomes exhibit controlled release and temperature-dependent degradation, suggesting potential for drug delivery.

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Area of Science:

  • Materials Science
  • Biotechnology
  • Physical Chemistry

Background:

  • Niosomes are vesicular systems typically formed using non-ionic surfactants and cholesterol.
  • Curcumin, a natural probiotic compound, has potential therapeutic applications but requires suitable delivery systems.

Purpose of the Study:

  • To investigate the formation and stabilization of niosomes using Tween 80 (T80) and Tween 20 (T20) with curcumin.
  • To characterize the structural and thermal properties of these novel Tween-curcumin niosomes.
  • To explore the temperature-dependent stability and curcumin release kinetics.

Main Methods:

  • Niosome preparation using Tween surfactants and curcumin.
  • Characterization via Dynamic Light Scattering (DLS), zeta potential, Scanning Electron Microscopy (SEM), Atomic Force Microscopy (AFM), and Transmission Electron Microscopy (TEM).
  • Investigation of micelle-vesicle transitions and temperature-dependent degradation using fluorescence anisotropy, fluorescence lifetime, absorption, and Differential Scanning Calorimetry (DSC).

Main Results:

  • Curcumin acts as a stabilizing agent in Tween-based niosomes, similar to cholesterol.
  • Niosomes are stable at room temperature but degrade irreversibly to micelles at elevated temperatures (333 K).
  • Controlled release of curcumin from the prepared niosomes was observed.

Conclusions:

  • Curcumin can effectively form and stabilize niosomes with Tween surfactants, offering an alternative to cholesterol.
  • The temperature-dependent degradation profile and controlled release suggest potential for curcumin delivery and multidrug therapy applications.