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Dual antiplatelet therapy in coronary artery disease: from the past to the future prospective

Antonio Mangieri1, Francesco Gallo2, Alessandro Sticchi2

  • 1GVM Care and Research, Maria Cecilia Hospital, Cotignola, Ravenna, Italy. antonio.mangieri@gmail.com.

Cardiovascular Intervention and Therapeutics
|January 24, 2020
PubMed

Insights

Dual antiplatelet therapy is crucial for preventing adverse events after coronary stenting. Newer agents allow personalized antithrombotic strategies based on patient risk profiles.

Area of Science:

  • Cardiology
  • Pharmacology

Background:

  • Antiplatelet therapy is essential for patients undergoing coronary stenting.
  • It significantly reduces adverse clinical events in acute coronary syndrome and stable coronary artery disease.

Purpose of the Study:

  • To review the history and evolution of dual antiplatelet therapy.
  • To discuss current evidence and future directions in antithrombotic management for coronary artery disease.

Main Methods:

  • Literature review of antiplatelet and anticoagulant therapies.
  • Analysis of clinical trial data and guidelines.

Main Results:

  • Dual antiplatelet therapy is a cornerstone in post-stent treatment.
  • Emerging antiplatelet and anticoagulant agents offer tailored treatment options.

Conclusions:

  • Personalized antithrombotic strategies are key for managing bleeding and ischemic risks.
  • Continued research is vital for optimizing patient outcomes in coronary artery disease.

Keywords:
Acute coronary syndromesAspirinBleedingDirect oral anticoagulantsDual antiplatelet therapyMyocardial infarctionP2Y12 inhibitorsStent thrombosis

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